Acute treadmill exercise discriminately improves the skeletal muscle insulin-stimulated growth signaling responses in mice lacking REDD1

Physiological Reports
Cory M DunganDavid L Williamson

Abstract

A loss of the regulated in development and DNA damage 1 (REDD1) hyperactivates mechanistic Target of Rapamycin Complex 1 (mTORC1) reducing insulin-stimulated insulin signaling, which could provide insight into mechanisms of insulin resistance. Although aerobic exercise acutely inhibits mTORC1 signaling, improvements in insulin-stimulated signaling are exhibited. The goal of this study was to determine if a single bout of treadmill exercise was sufficient to improve insulin signaling in mice lacking REDD1. REDD1 wildtype (WT) and REDD1 knockout (KO) mice were acutely exercised on a treadmill (30 min, 20 m/min, 5% grade). A within animal noninsulin-to-insulin-stimulated percent change in skeletal muscle insulin-stimulated kinases (IRS-1, ERK1/2, Akt), growth signaling activation (4E-BP1, S6K1), and markers of growth repression (REDD1, AMPK, FOXO1/3A) was examined, following no exercise control or an acute bout of exercise. Unlike REDD1 KO mice, REDD1 WT mice exhibited an increase (P < 0.05) in REDD1 following treadmill exercise. However, both REDD1 WT and KO mice exhibited an increase (P < 0.05) AMPK phosphorylation, and a subsequent reduction (P < 0.05) in mTORC1 signaling after the exercise bout versus nonexercising WT or KO mi...Continue Reading

References

May 18, 1999·Molecular and Cellular Biology·Q WangA Klip
Mar 9, 2002·Molecular and Cellular Biology·Tzipora ShoshaniElena Feinstein
Aug 13, 2002·Nature Cell Biology·Christopher J PotterTian Xu
May 9, 2003·The Journal of Biological Chemistry·Zhengqi WangClark W Distelhorst
Jul 17, 2003·Acta Physiologica Scandinavica·N B RudermanA K Saha
May 20, 2004·Molecular Cell·Karen C Arden
Sep 29, 2004·Investigative Ophthalmology & Visual Science·Anat BrafmanTzipora Shoshani
Mar 23, 2005·The Journal of Biological Chemistry·Carsten SkurkKenneth Walsh
Feb 6, 2007·Nature Cell Biology·Emilie Vander HaarDo-Hyung Kim
Aug 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Frédéric TremblayAndré Marette
Jan 17, 2008·Genes & Development·Maurice Phillip DeYoungLeif W Ellisen
Apr 29, 2008·Molecular Cell·Dana M GwinnReuben J Shaw
Sep 3, 2008·Cell Metabolism·Thomas PorstmannAlmut Schulze
Oct 2, 2009·Journal of Cellular Biochemistry·Robert A FrostCharles H Lang
Nov 17, 2009·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Taesik GwagInho Choi
Aug 20, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew P HarberPaul T Reidy
Jan 29, 2011·Biochemical and Biophysical Research Communications·Taro MurakamiMariko Yoshinaga
Feb 22, 2012·Journal of Applied Physiology·Cécile JamartLéonard Féasson
May 17, 2012·Aging Cell·John E WilkinsonRichard A Miller
Aug 31, 2012·American Journal of Physiology. Cell Physiology·Tova Neustadt SchachterMartin F Schneider
Oct 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Florian A BrittoFrançois B Favier
Dec 3, 2014·Biochemical and Biophysical Research Communications·Cory M DunganDavid L Williamson
Aug 14, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David L WilliamsonJacob M Haus
Dec 4, 2016·Biochemical and Biophysical Research Communications·Cory M Dungan, David L Williamson
Sep 14, 2017·American Journal of Physiology. Endocrinology and Metabolism·Bradley S GordonPaul M Coen

❮ Previous
Next ❯

Citations

Feb 6, 2020·Experimental Physiology·Michelle CurranParth Narendran
Jun 7, 2019·Physiological Reports
Sep 3, 2020·American Journal of Physiology. Cell Physiology·Florian A BrittoFrancois B Favier
May 8, 2021·Aging·Pianpian HuangBenling Qi

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis

Software Mentioned

Bio
Rad ImageLab
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.