Acute treatment of bipolar depression with adjunctive zonisamide: a retrospective chart review

Bipolar Disorders
Claudia F BaldassanoMelissa Lipari

Abstract

This retrospective chart review evaluated the use of zonisamide as adjunctive treatment in patients with bipolar depression. The charts of outpatients with bipolar I or II disorder treated with adjunctive zonisamide were reviewed. The efficacy of zonisamide was assessed via comparison of physician-rated Global Assessment of Functioning (GAF) and Clinical Global Impression of Severity (CGI-S) Scale scores at baseline and after 6 weeks of therapy using paired t-tests. Patients who scored < or = 2 on the CGI-S after 6 weeks of zonisamide therapy were considered good responders to zonisamide. Charts for 12 patients (four men and eight women) with a mean (+/- SD) age of 39.6 (+/- 7.6) years were evaluated. Patients received a mean (+/- SD) zonisamide dosage of 236 (+/- 68) mg/day. Mean GAF scores significantly improved from 44.0 at baseline to 59.3 at week 6 (P = 0.05). Mean CGI-S scores improved from 4.54 at baseline to 3.42 at week 6, but the change was not statistically significant. Six patients (50.0%) were considered responders to zonisamide. Four patients discontinued zonisamide therapy, two for an adverse event (sedation) and two for lack of efficacy. Zonisamide may be a useful adjunctive treatment for some patients with bipo...Continue Reading

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Bipolar Disorder

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