Acute treatment of mania in children and adolescents

Current Opinion in Psychiatry
Philip Hazell, Rajeev Jairam

Abstract

To examine critically data concerning the efficacy and safety of acute treatments for mania in children and adolescents, in the light of considerable recent emergent evidence. We found consistent evidence favouring the use of second-generation antipsychotics (SGAs), limited evidence favouring the use of combinations of SGA with a mood stabilizer, and no evidence supporting the use of mood stabilizer monotherapy in this context. Various SGA drugs are not clearly separated in terms of efficacy, but do differ in their side-effect profiles. There are insufficient data to comment on the benefit of alternative treatments, psychological treatments and electroconvulsive therapy. The presence of common comorbidities has an inconsistent influence on clinical effectiveness. First-line treatment for mania in children and adolescents is a SGA, with combination therapies offering no clear advantage. Gaps in our knowledge remain about expected time to recovery, and when to augment or change treatment when there is lack of effect.

References

Sep 18, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·B Geller, J Luby
Jan 2, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Jon McClellanUNKNOWN Work Group on Quality Issues
Aug 2, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Jon McCLELLANJeffrey A Lieberman
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Joseph BiedermanEric Mick
Aug 19, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Argyris StringarisRobert Goodman
May 6, 2010·CNS Drugs·Jonathan C PfeiferMelissa P DelBello
Sep 28, 2010·Bipolar Disorders·Mani N PavuluriJohn A Sweeney
Feb 2, 2011·Pediatric Clinics of North America·Tiffany ThomasRobert L Findling
May 10, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alessandro ZuddasTatiana Usala
Jun 15, 2011·Journal of Child and Adolescent Psychopharmacology·Robert L FindlingPerdita Taylor-Zapata
Jul 26, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Howard Y LiuJoseph Biederman
Nov 26, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Mani N Pavuluri

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Citations

Oct 18, 2019·The Cochrane Database of Systematic Reviews·Janina JochimAndrea Cipriani

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