Abstract
A considerable body of evidence indicates the involvement of the neurotransmitter serotonin (5-HT) in the pathogenesis and treatment of depression. The acute effect of fluvoxamine, on 5-HT synthesis rates was investigated in rat brain regions, using α-(14)C-methyl-L-tryptophan as a tracer. Fluvoxamine (25 mg/kg) and saline (control) were injected intraperitoneally, one hour before the injection of the tracer (30 μCi). There was no significant effect of fluvoxamine on plasma free tryptophan. After Benjamini-Hochberg False Discovery Rate correction, a significant decrease in the 5-HT synthesis rate in the fluvoxamine treated rats, was found in the raphe magnus (-32%), but not in the median (-14%) and dorsal (-3%) raphe nuclei. In the regions with serotonergic axon terminals, significant increases in synthesis rates were observed in the dorsal (+41%) and ventral (+43%) hippocampus, visual (+38%), auditory (+65%) and parietal (+37%) cortex, and the substantia nigra pars compacta (+56%). There were no significant changes in the 5-HT synthesis rates in the median (+11%) and lateral (+24%) part of the caudate-putamen, nucleus accumbens (+5%), VTA (+16%) or frontal cortex (+ 6%). The data show that the acute administration of fluvoxami...Continue Reading
References
Dec 8, 1992·European Journal of Pharmacology·N Bel, F Artigas
Feb 15, 1991·Biochemical Pharmacology·P A JohansenD M Kuhn
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M DiksicY L Yamamoto
Jan 1, 1985·The Journal of Pharmacy and Pharmacology·P C Waldmeier
May 1, 1995·Neuropharmacology·F J BoskerH G Westenberg
Mar 1, 1994·International Clinical Psychopharmacology·J Hyttel
Oct 1, 1993·Neurochemistry International·A TakadaY L Yamamoto
Sep 1, 1993·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S MzengezaM Diksic
Feb 9, 1993·European Journal of Pharmacology·F JenckW E Haefely
Oct 27, 1998·Biological Psychiatry·J K StaleyR B Innis
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Jun 22, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Y TohyamaM Diksic
Mar 20, 2002·Molecular Pharmacology·Seong Who KimOnyou Hwang
Mar 29, 2002·Psychopharmacology·Frank P BymasterKenneth W Perry
May 13, 2004·Psychopharmacology·Damiaan DenysHerman G M Westenberg
Dec 25, 2004·Psychopharmacology·Shu HasegawaMirko Diksic
Jan 5, 2006·The American Journal of Psychiatry·Gregory E SimonPhilip S Wang
Mar 15, 2006·Brain Research Bulletin·Arata WatanabeMirko Diksic
Jun 17, 2006·Therapeutic Drug Monitoring·Takashi FukasawaKoichi Otani
Mar 14, 2007·European Journal of Pharmacology·Nobuaki EgashiraMichihiro Fujiwara
Aug 5, 2008·Brain Research Bulletin·Kazuya KanemaruMirko Diksic
Aug 12, 2008·Journal of Affective Disorders·Eric G Smith
Dec 17, 2008·Neurochemistry International·Khanh Q NguyenMirko Diksic
Sep 28, 2010·Neuroscience·L MacGillivrayM F Mazurek
Mar 19, 2011·Neurochemistry International·Nela Pivac, Mirko Diksic
Apr 14, 2011·Psychopharmacology·Yukio AgoToshio Matsuda
Citations
Mar 21, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mounir Maafi, Wassila Maafi
Jan 16, 2015·Behavioural Pharmacology·Momen W AlhajYasser M Moustafa
Jun 25, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ernest DalléMusa V Mabandla
Aug 30, 2016·Behavioural Brain Research·Ernest DalléMusa V Mabandla
May 28, 2017·Brain Research Bulletin·Ernest DalléMusa V Mabandla
Mar 20, 2018·Molecular Brain·Ernest Dallé, Musa V Mabandla
Mar 29, 2014·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Gabriela K FerreiraEmilio L Streck
Apr 29, 2020·Journal of Drug Assessment·Yogita Tyagi, Nv Satheesh Madhav
Apr 11, 2020·Oxidative Medicine and Cellular Longevity·Ernest DalléMusa V Mabandla