Acute tryptophan depletion reduces activation in the right hippocampus during encoding in an episodic memory task

NeuroImage
F M van der VeenJeroen A J Schmitt

Abstract

Acute tryptophan depletion (ATD), a well-recognized method to lower central serotonin levels, was used to examine the effects of lower central serotonin levels on memory function in healthy males. Functional Magnetic Resonance Imaging (fMRI) was used to examine changes in brain activation during the encoding and the retrieval phase of a visual verbal episodic memory task. ATD led to more positively rated words in the encoding phase and to poorer recognition of these positively rated words in the retrieval phase. Furthermore, encoding was accompanied by enhanced brain activation in occipital, middle and superior frontal, anterior and posterior cingulate and striatal areas. Retrieval attempt was accompanied by enhanced activation in the cuneus, inferior occipital gyrus and inferior and middle frontal areas. Retrieval success was accompanied by activation in an extensive network including frontal, parietal, temporal, cingulate, striatal and cerebellar areas. In the encoding phase ATD attenuated activation in the right hippocampus and ATD did not affect brain activity in the retrieval phase. These results show that serotonin is important in long term memory processes, and that serotonin acts on the encoding phase and not on the ret...Continue Reading

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Citations

Jun 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebecca ElliottIan M Anderson
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Andreas HahnRupert Lanzenberger
Jul 25, 2009·Social Cognitive and Affective Neuroscience·Lihong WangScott A Huettel
Oct 31, 2013·Neurochemical Research·Haipeng LiuPeng Xie
Sep 1, 2009·Neuroscience and Biobehavioral Reviews·B Y Silber, J A J Schmitt
May 12, 2009·Neuroscience and Biobehavioral Reviews·Daniel MendelsohnAnke Sambeth
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Mar 24, 2009·Journal of Psychopharmacology·F M Van der VeenJ Jolles
Dec 17, 2009·Neuroscience and Behavioral Physiology·I G Sil'kis

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