Acute tubular nephropathy in a patient with acute HIV infection: review of the literature

AIDS Research and Therapy
Jintanat AnanworanichJerome H Kim

Abstract

We report a 57-year old man with diabetes mellitus and hypertension who presented with acute HIV infection. Routine blood tests showed an elevated blood urea nitrogen and creatinine. Renal biopsy showed acute tubular nephropathy, which has not been reported to occur during acute HIV infection, in the absence of rhabdomyolysis or multiple organ system failure. Antiretroviral therapy was initiated. His renal failure gradually resolved without further intervention. At one year of follow-up his HIV RNA was undetectable, and his renal function was normal. The case illustrates a rare manifestation of acute HIV infection - acute renal failure - in an older man with diabetes and hypertension. In this setting acute kidney injury might mistakenly have been attributed to his chronic comorbidities, and this case supports early HIV-1 testing in the setting of a high index of suspicion.

References

Feb 13, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P G Meneton, D Warnock
Jul 23, 2002·AIDS Patient Care and STDs·Susan SzaboGeorgianna Telford
Apr 23, 2005·Adolescent Medicine Clinics·Carolyn L AbitbolGastón Zilleruelo
Nov 26, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·José Ramón Paño-PardoGordon Dickinson
Jan 31, 2012·Intervirology·Stefan ReuterDieter Häussinger
May 4, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Symeon MetallidisPavlos Nikolaidis
May 31, 2013·Retrovirology·Jintanat AnanworanichUNKNOWN RV254/SEARCH 010 Study Group
Dec 7, 2013·Journal of the American Society of Nephrology : JASN·Guillaume CanaudChristophe Legendre

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Citations

Feb 14, 2020·Scandinavian Journal of Immunology·Babatunde A OlusolaGeorgina N Odaibo

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Methods Mentioned

BETA
biopsy
electron microscopy

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