Acute tubulointerstitial nephritis associated with piperacillin therapy in a boy with glomerulonephritis

Acta Paediatrica Japonica; Overseas Edition
H TanakaM Yokoyama

Abstract

An 11-year-old boy with glomerulonephritis developed acute renal failure 4 days after beginning piperacillin (PIPC) treatment. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN) with marked eosinophils. A lymphocyte stimulation test (LST) for PIPC demonstrated an extremely high LST index of 626%. The serum levels of immunoglobulin E and eosinophil cationic protein also showed a significant increase at 9021 IU/mL and greater than 150 micrograms/L, respectively. These observations suggest that a hypersensitivity reaction might play a role in the pathogenesis of ATIN. This is the first report to describe PIPC-induced ATIN in a child.

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Citations

Aug 24, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Koji TsugawaHiroshi Tanaka
Apr 15, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Tatsuya ItoHiroshi Tanaka
Feb 24, 2001·The Tohoku Journal of Experimental Medicine·H TanakaN Monma
Nov 29, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Manal Abouelkheir, Sarah Alsubaie

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