PMID: 6976301Jan 1, 1982Paper

Acute type B hepatitis among HBsAg negative patients detected by anti-HBc IgM

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
P KrygerJ O Nielsen

Abstract

A consecutive group of 169 patients with acute hepatitis found negative for hepatitis B surface antigen (HBsAg) and negative for IgM antibody against hepatitis A (anti-HAV IgM) was studied for presence of IgM antibody against hepatitis B core antigen (anti-HBc IgM) by ELISA. Anti-HBc IgM was found in a total of 34 of 60 patients with detectable total anti-HBc. One hundred and nine patients had no detectable anti-HBc IgM and no total anti-HBc and were thus considered as having acute non-A, non-B hepatitis. Among the 34 patients with anti-HBc IgM in their first serum sample, 23 were anti-HBs negative and all had high and steadily decreasing ratio unit (RU) values for anti-HBc IgM (mean RU value 17.1). Twelve of the 23 patients showed seroconversion to anti-HBs during the follow-up, indicating an actual hepatitis B virus infection. Eleven of the 34 anti-HBc IgM positive patients had anti-HBs in their first serum sample. In this group, the RU values for anti-HBc IgM were high and steadily declining and the initial values were significantly lower (mean RU value 9.9) (p less than 0.05) than in the anti-HBs negative group. Evidence is provided that anti-HBc IgM in serum from patients with HBsAg negative hepatitis with or without anti-...Continue Reading

References

Nov 1, 1979·Journal of Clinical Microbiology·A M Møller, L R Mathiesen
Jan 18, 1979·The New England Journal of Medicine·S KrugmanF Deinhardt
Jun 1, 1980·Journal of Clinical Microbiology·R A HawkesN I Lehmann
May 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P KrygerJ O Nielsen

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Citations

Nov 1, 1985·Digestive Diseases and Sciences·J H HoofnagleL B Seeff
Sep 3, 1984·Klinische Wochenschrift·K GmelinB Kommerell
May 1, 1984·Infection·J Fasel-FelleyP C Frei
Apr 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M ButtarelloP Rizzotti
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J BernuauJ P Benhamou
Mar 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K H ChauL R Overby
Feb 11, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R LeonE R Schiff
Mar 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H Hoofnagle
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M C LaiS D Lee
Sep 1, 1985·Acta Pathologica Japonica·K TanakaN Kawano
May 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KoikeH Oka

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