Acute vagus nerve stimulation does not suppress spike and wave discharges in genetic absence epilepsy rats from Strasbourg

Epilepsy Research
Stefanie DedeurwaerdereP Boon

Abstract

We evaluated the efficacy of vagus nerve stimulation (VNS) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a validated model for absence epilepsy. In the first experiment, we investigated whether VNS applied at seizure onset can interrupt spike and wave discharges (SWD). In the second experiment, we investigated whether SWD are suppressed or shortened in duration when VNS is applied several hours per day. Both control and VNS groups underwent EEG and VNS electrode implantation. For the first experiment, a randomized crossover design was used. Stimuli (amplitude: 3 V; frequency: 30 Hz; pulse duration: 500 micros) were given when an SWD occurred on the EEG. The experiment was repeated the next day. In the second experiment, treated animals were stimulated (amplitude: 1.5 mA; frequency: 30 Hz; pulse duration: 500 micros; on/off time cycle: 30 s / 5 min) for 3h per day, during five consecutive days. In the first experiment, the duration of the SWD was increased on day 1, (P < 0.05). There was no difference in SWD duration on Day 2. In the second experiment, no significant differences could be found in number, duration and EEG frequency of SWD. VNS applied at the onset of an SWD can prolong the duration of SWD in GAERS. As...Continue Reading

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Citations

Nov 1, 2005·Medical & Biological Engineering & Computing·M A ThilJ Delbeke
Oct 13, 2009·Epilepsia·Victor M Magdaleno-MadrigalRodrigo Fernández-Mas
Sep 11, 2012·Epilepsia·Georgia M Alexander, James O McNamara
Nov 20, 2013·Epilepsy Research·Víctor Manuel Magdaleno-MadrigalRodrigo Fernández-Mas
May 14, 2011·Experimental Neurology·Marlien AalbersKim Rijkers
Feb 10, 2009·Autonomic Neuroscience : Basic & Clinical·M W AalbersH J M Majoie
Nov 18, 2005·Epilepsy Research·Stefanie DedeurwaerderePaul Boon
Mar 25, 2009·The International Journal of Neuropsychopharmacology·Francesca BiggioPaolo Follesa
Dec 23, 2014·PloS One·Peter Neal TaylorGerold Baier

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