Acute VEGF effect on solute permeability of mammalian microvessels in vivo

Microvascular Research
Bingmei M Fu, Shang Shen

Abstract

To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently increased P from a mean of 1.4 (+/-0.11 SE, n = 17) to a peak of 2.8 (+/-0.28 SE) x 10(-5) cm/s, a 2.4-fold increase for small solute sodium fluorescein (Stokes radius 0.45 nm), from a mean of 0.44 (+/-0.05 SE, n = 16) to a peak of 1.5 (+/-0.19 SE) x 10(-)5 cm/s, a 3.6-fold increase for intermediate-sized solute alpha-lactalbumin (Stokes radius 2.01 nm), from a mean of 0.049 (+/-0.0032 SE, n = 16) to a peak of 0.36 (+/-0.032 SE) x 10(-5) cm/s, a 7.9-fold increase for large solute bovine serum albumin (Stokes radius 3.55 nm), within 30 s. In approximately 2 min, all increased P returned to the baseline values. The response pattern of P to VEGF and the ratios of the peak to control values for rat mesenteric microvessels are similar to those of frog mesenteric microvessels [Am. J. Physiol.: Heart Circ. Physiol. 284 (2003) H2124]. Instead of considerable heterogeneity in the frog mesenteric microvessels, the acute response to 1 nM VEGF is homogeneous in the ra...Continue Reading

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Citations

Jun 10, 2010·Biomechanics and Modeling in Mechanobiology·Qin LiuBingmei M Fu
Aug 6, 2011·Biomechanics and Modeling in Mechanobiology·W W YanB M Fu
Apr 6, 2012·Annals of Biomedical Engineering·Bingmei M Fu, Yang Liu
Apr 20, 2010·Cardiovascular Research·David O Bates
Jun 15, 2010·Cardiovascular Research·John M Tarbell
Apr 18, 2006·Critical Care Medicine·Christopher C Silliman
Feb 2, 2011·Journal of Biomechanical Engineering·Guanglei Li, Bingmei M Fu
Aug 7, 2012·American Journal of Physiology. Heart and Circulatory Physiology·F E CurryR H Adamson
Jul 25, 2013·Biomechanics and Modeling in Mechanobiology·Peng GuoBingmei M Fu
Oct 8, 2008·Microvascular Research·Wei YuanBingmei M Fu
Jul 29, 2008·Journal of Biomechanics·Qin LiuBingmei M Fu
Dec 20, 2005·Blood Reviews·Christopher C Silliman, Nathan J D McLaughlin
Apr 7, 2010·Microvascular Research·Wei YuanBingmei M Fu
Feb 22, 2012·Microvascular Research·Wan-Yi YenBingmei M Fu
Mar 26, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Lin ZhangBingmei M Fu
Aug 27, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Veronika RamovsArnoud Sonnenberg
Sep 15, 2015·Lab on a Chip·Max I BogoradPeter C Searson
Dec 24, 2017·Scientific Reports·V van DuinenT Hankemeier
Nov 7, 2013·Journal of Biomechanical Engineering·Lingyan ShiBingmei M Fu
Dec 2, 2004·Blood·Christopher C SillimanLynn K Boshkov
Nov 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yan QiuSteven J Harper
Apr 10, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Lin ZhangBingmei M Fu
Sep 24, 2020·Advanced Healthcare Materials·Chun-Wei ChiSihong Wang
Oct 16, 2021·Frontiers in Cell and Developmental Biology·Yifan XiaBingmei M Fu
Nov 13, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Feng GaoPingnian He

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