PMID: 7536098Jan 1, 1995Paper

Acute versus chronic administration of phosphodiesterase inhibitors on allergen-induced pulmonary cell influx in sensitized guinea-pigs

British Journal of Pharmacology
K H Banner, C P Page

Abstract

1. The aims of this study were to determine which phosphodiesterase (PDE) isoenzymes are involved in the control of eosinophil accumulation in the airways of ovalbumin (OVA)-immunized guinea-pigs by the use of isoenzyme selective inhibitors and to compare the effects of acute versus chronic administration of PDE isozyme inhibitors on pulmonary cell influx in ovalbumin-immunized guinea-pigs. 2. Guinea-pigs were sensitized and subsequently challenged with aerosolized OVA. Twenty four hours later bronchoalveolar lavage (BAL) was performed to permit assessment of inflammatory cell accumulation. A significant increase in the number of eosinophils was observed in the lavage fluid from OVA-immunized (13.6 +/- 1.4 x 10(4) ml-1 in acute experiments and 10.1 +/- 1.4 x 10(4) ml-1 in chronic experiments) animals compared with sham-treated controls (5.6 +/- 0.6 x 10(4) ml-1 in acute experiments and 5.1 +/- 0.6 x 10(4) ml-1 in chronic experiments). There was no difference in neutrophil, mononuclear cell or total cell numbers between the two groups. 3. Acute administration of a high dose of selective and non-selective PDE inhibitors by the i.p. route had no significant effect on eosinophil accumulation in the airways. 4. Chronic administratio...Continue Reading

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Aug 1, 1996·Trends in Pharmacological Sciences·T MüllerJ R Fozard
Jun 14, 2000·European Journal of Pharmacology·R PonsE J Morcillo
May 1, 1997·Trends in Pharmacological Sciences·M M TeixeiraP G Hellewell
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Mar 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K H Banner, C P Page
Mar 25, 2021·Journal of Experimental Pharmacology·Maria Gabriella MateraMario Cazzola
Feb 24, 2006·Bioorganic & Medicinal Chemistry·Edward C LawsonBruce E Maryanoff

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