Acute virulence in mice is associated with markers on chromosome VIII in Toxoplasma gondii.

Infection and Immunity
D K HoweL D Sibley

Abstract

Toxoplasma gondii has an unusual population structure consisting of three widely distributed clonal lineages. Acute virulence in mice is strictly observed in type I strains, indicating that a genetic determinant(s) unique to this lineage controls acute pathogenesis. We have analyzed several naturally occurring recombinant strains of T. gondii that carry allele 1 at the SAG1 locus; this allele is characteristic of the type I strains and was previously found to be 100% correlated with the acute virulence phenotype. Recombinant strains G622-M and ROD both had a predominantly type III genotype, with the significant exception of allele 1 at the SAG1 locus. Although these two strains had virtually identical multilocus genotypes, they differed in their virulence in mice. Strain ROD was virulent whereas strain G622-M was nonvirulent, thus demonstrating that the presence of allele 1 at SAG1 is not alone sufficient to confer acute virulence. Several sequence polymorphisms upstream of SAG1 were found to be highly correlated with the acutely virulent lineages. Collectively, these results suggest that acute virulence is regulated by a region linked to the SAG1 locus on chromosome VIII in T. gondii.

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Citations

Jul 1, 2016·Annual Review of Microbiology·Michael S BehnkeL David Sibley
Feb 24, 2006·Emerging Infectious Diseases·Lenildo de MouraDenise O Garrett
Nov 25, 2003·The Journal of Parasitology·J P DubeyT Y Morishita
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chunlei SuL David Sibley
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L C Gavrilescu, E Y Denkers
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jon P BoyleJohn C Boothroyd
Jul 10, 2001·Parasitology·P Ambroise-Thomas
Mar 16, 2019·Parasites & Vectors·Clare M HamiltonFrank Katzer
Feb 13, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L David SibleyDan K Howe
Sep 16, 2003·Journal of Leukocyte Biology·Dana G Mordue, L David Sibley
Jul 21, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sarah J Fentress, L David Sibley
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul M RobbenL David Sibley
Aug 19, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L David SibleyBenjamin M Rosenthal
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Jan 22, 2019·Frontiers in Cellular and Infection Microbiology·Roberto Sánchez-SánchezJulio Benavides
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Jun 1, 2021·Frontiers in Cellular and Infection Microbiology·Geraldo Magela de Faria JuniorLuiz Carlos de Mattos

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