Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations

Frontiers in Immunology
Jéssica Barletto de Sousa BarrosIrmtraut Araci Hoffmann Pfrimer

Abstract

An early immune response to Zika virus (ZIKV) infection may determine its clinical manifestation and outcome, including neurological effects. However, low-grade and transient viremia limits the prompt diagnosis of acute ZIKV infection. We have investigated the plasma cytokine, chemokine, and growth factor profiles of 36 individuals from an endemic area displaying different symptoms such as exanthema, headache, myalgia, arthralgia, fever, hyperemia, swelling, itching, and nausea during early-phase infection. These profiles were then associated with symptoms, revealing important aspects of the immunopathophysiology of ZIKV infection. The levels of some cytokines/chemokines were significantly higher in acute ZIKV-infected individuals compared to healthy donors, including interferon (IFN) gamma-induced protein 10 (IP-10), regulated on activation, normal T cell expressed and secreted (RANTES), IFN-γ, interleukin (IL)-9, IL-7, IL-5, and IL-1ra, including some with predominantly immunoregulatory activity. Of note, we found that higher levels of IP-10 and IL-5 in ZIKV-infected individuals were strongly associated with exanthema and headache, respectively. Also, higher levels of IL-1ra were associated with subjects with arthralgia, wher...Continue Reading

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Citations

Jun 9, 2020·PLoS Neglected Tropical Diseases·Mahamud-Ur RashidKevin M Coombs
Dec 24, 2019·Frontiers in Microbiology·Lili WangFei Yu
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Dec 31, 2020·PloS One·Jennifer L Spencer ClintonRebecca Rico-Hesse
Apr 28, 2021·Mucosal Immunology·Evgeniya V Shmeleva, Francesco Colucci
Jun 2, 2020·Virus Research·Joel Henrique EllwangerJosé Artur Bogo Chies
Jan 9, 2022·Scientific Reports·Ana Clara Barbosa AntonelliSimone Gonçalves Fonseca

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Methods Mentioned

BETA
urine collection
second
blood collection
enzyme-linked immunosorbent assays

Software Mentioned

GraphPad Prism
R
Cytoscape
ggplot
corrplot
heatmap2
R package “ randomForest ”
GraphPad
Bio
Plex Manager

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