PMID: 9551196Apr 29, 1998Paper

Acyclic nucleotide analogues based on phosphonic acids

Bioorganicheskaia khimiia
E V EfimtsevaE De Clercq

Abstract

The synthesis of novel nucleotide analogues on the basis of ethylphosphonic acid was described. A rigid structural element, an amide or a double bond, was characteristics of the compounds synthesized. The antiviral and cytotoxic activities of these compounds were studied in cell cultures.

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