Abstract
Cytomegalovirus (CMV) is an opportunistic infection that causes profound morbidity and mortality after orthotopic liver transplant (OLT). The CMV immunoglobulin G serostatuses of donors and recipients are the main factors influencing risk for development of CMV infection after transplant. To compare acyclovir and valganciclovir for preventing CMV infection after OLT. Retrospective assessment of adult OLT recipients at intermediate risk for CMV infection at New York Presbyterian Hospital. All patients received ganciclovir 5 mg/kg intravenously every 12 hours or valganciclovir 900 mg orally every 12 hours for 7 days after transplant. On postoperative day 8, patients received antiviral prophylaxis according to risk stratification: acyclovir 800 mg orally 3 times daily in donor seronegative/recipient seropositive (D-/R+) patients or valganciclovir 900 mg orally once daily in donor seropositive/recipient seropositive (D+/R+) patients. Composite incidence of CMV infection, syndrome, or tissue-invasive disease. Of 275 OLT recipients, 89 were at intermediate risk for CMV infection (29 D-/R+, 60 D+/R+). CMV infection, syndrome, or tissue-invasive disease occurred in 1 patient (3%) in the D-/R+ group and 5 patients (8%) in the D+/R+ grou...Continue Reading
References
Jul 8, 1995·Lancet·D J WinstonR W Busuttil
Jan 1, 1997·Transplant International : Official Journal of the European Society for Organ Transplantation·J GavaldàA Pahissa
Jan 28, 2003·Transplantation·Drew J Winston, Ronald W Busuttil
May 26, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nina SinghThomas V Cacciarelli
Dec 21, 2007·The New England Journal of Medicine·Jay A Fishman
Oct 3, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H-Y SunN Singh
Mar 30, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jong Man KimSuk-Koo Lee
May 28, 2011·Transplantation·Elizabeth C VernaRobert S Brown
Nov 22, 2011·Bioscience Trends·Junichi TogashiNorihiro Kokudo
Apr 26, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marta BodroJordi Carratalà
Aug 14, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andre C KalilDiana F Florescu
Aug 21, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Manav WadhawanAjay Kumar
Jan 3, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael R LuceyLewis W Teperman
Feb 14, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Irmeli LautenschlagerKrister Höckerstedt
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R R RazonableUNKNOWN AST Infectious Diseases Community of Practice
Citations
Aug 29, 2017·The Annals of Pharmacotherapy·Margaret R JorgensonRobert R Redfield
May 8, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Puja S BerryRobert G Sawyer
Jun 6, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Klara ChmelovaJan Sperl
May 26, 2018·Pharmacotherapy·Magdalena SiodlakRobert R Redfield