Acyl chain-length asymmetry alters the interfacial elastic interactions of phosphatidylcholines

Biophysical Journal
S AliR E Brown

Abstract

Phosphatidylcholines (PCs) with stearoyl (18:0) sn-1 chains and variable-length, saturated sn-2 acyl chains were synthesized and investigated using a Langmuir-type film balance. Surface pressure was monitored as a function of lipid molecular area at various constant temperatures between 10 degrees C and 30 degrees C. Over this temperature range, 18:0-10:0 PC displayed only liquid-expanded behavior. In contrast, di-14:0 PC displayed liquid-expanded behavior at 24 degrees C and 30 degrees C, but two-dimensional phase transitions were evident at 20 degrees C, 15 degrees C, and 10 degrees C. The average molecular area of 18:0-10:0 PC was larger than that of liquid-expanded di-14:0 PC at equivalent surface pressures, and the shapes of their liquid expanded isotherms were somewhat dissimilar. Analysis of the elastic moduli of area compressibility (Cs(-1)) as a function of molecular area revealed shallower slopes in the semilog plots of 18:0-10:0 PC compared to di-14:0 PC. At membrane-like surface pressures (e.g., 30 mN/m), 18:0-10:0 PC was 20-25% more elastic (in an in-plane sense) than di-14:0 PC. Other PCs with varying degrees of chain-length asymmetry (18:0-8:0 PC, 18:0-12:0 PC, 18:0-14:0 PC, 18:0-16:0 PC) were also investigated t...Continue Reading

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Citations

Dec 2, 2011·Molecular Pharmaceutics·Abdelkader A MetwallyIan S Blagbrough
Aug 31, 2002·Biophysical Journal·Mohammed DahimHoward L Brockman
Aug 31, 2002·Biophysical Journal·Xin-Min LiRhoderick E Brown
Jul 11, 2006·Biophysical Journal·Xiuhong ZhaiRhoderick E Brown
Oct 12, 2000·Biophysical Journal·S L KellerH M McConnell
Jun 29, 2013·Biochimica Et Biophysica Acta·Milagro MottolaMaria Laura Fanani
May 26, 2004·Biochimica Et Biophysica Acta·Stephanie Nichols-SmithTonya L Kuhl
Jul 23, 2005·The Journal of Chemical Physics·G IllyaJ C Shillcock
Dec 15, 2004·The Journal of General Physiology·László CsanádyDavid C Gadsby
Feb 25, 2021·Physical Chemistry Chemical Physics : PCCP·N de LangeF A M Leermakers
Aug 29, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Clare M HollinsheadM Jayne Lawrence
May 29, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Minh D PhanKwanwoo Shin
May 9, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·An-Tsung KuoWataru Shinoda
Jan 8, 2002·Langmuir : the ACS Journal of Surfaces and Colloids·Xin-Min LiMusti J Swamy

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