Acyl-CoA-Binding Protein ACBP1 Modulates Sterol Synthesis during Embryogenesis

Plant Physiology
Shiu-Cheung LungMee-Len Chye

Abstract

Fatty acids (FAs) and sterols are primary metabolites that exert interrelated functions as structural and signaling lipids. Despite their common syntheses from acetyl-coenzyme A, homeostatic cross talk remains enigmatic. Six Arabidopsis (Arabidopsis thaliana) acyl-coenzyme A-binding proteins (ACBPs) are involved in FA metabolism. ACBP1 interacts with PHOSPHOLIPASE Dα1 and regulates phospholipid composition. Here, its specific role in the negative modulation of sterol synthesis during embryogenesis is reported. ACBP1, likely in a liganded state, interacts with STEROL C4-METHYL OXIDASE1-1 (SMO1-1), a rate-limiting enzyme in the sterol pathway. Proembryo abortion in the double mutant indicated that the ACBP1-SMO1-1 interaction is synthetic lethal, corroborating with their strong promoter activities in developing ovules. Gas chromatography-mass spectrometry revealed quantitative and compositional changes in FAs and sterols upon overexpression or mutation of ACBP1 and/or SMO1-1 Aberrant levels of these metabolites may account for the downstream defect in lipid signaling. GLABRA2 (GL2), encoding a phospholipid/sterol-binding homeodomain transcription factor, was up-regulated in developing seeds of acbp1, smo1-1, and ACBP1+/-smo1-1 in...Continue Reading

Citations

Feb 10, 2018·Frontiers in Plant Science·Tai-Hua HuMee-Len Chye
Jan 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sylvain Darnet, Hubert Schaller
Jan 25, 2019·The New Phytologist·Shiu-Cheung Lung, Mee-Len Chye
Aug 23, 2019·The Plant Journal : for Cell and Molecular Biology·Ze-Hua GuoMee-Len Chye
Apr 16, 2019·Frontiers in Plant Science·Siddique I Aboobucker, Walter P Suza
Sep 12, 2020·Scientific Reports·Saritha Panthapulakkal NarayananMee-Len Chye
Jun 7, 2018·Frontiers in Genetics·Nadia RaboanatahiryMaoteng Li
Oct 18, 2020·International Journal of Molecular Sciences·Shuo SunHuixia Shou
May 4, 2021·Frontiers in Plant Science·Nur Syifaq AzlanMee-Len Chye
Nov 19, 2021·Journal of Experimental Botany·Mohd Fadhli HamdanMee-Len Chye

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