Acyl-coenzyme A:cholesterol acyltransferases.

American Journal of Physiology. Endocrinology and Metabolism
Ta-Yuan ChangYasuomi Urano

Abstract

The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.

References

Aug 1, 1995·Circulation·E FalkV Fuster
May 31, 1996·Science·H YangS L Sturley
Apr 29, 1998·Current Opinion in Lipidology·R V Farese
Oct 3, 1998·The Journal of Biological Chemistry·P OelkersS L Sturley
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·A MiyazakiT Y Chang
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·S CasesR V Farese
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jun 10, 2000·The Journal of Biological Chemistry·C C ChangT Y Chang
Dec 9, 2000·Biochimica Et Biophysica Acta·K F BuhmanR V Farese
Feb 13, 2001·The Journal of Clinical Investigation·S FazioR V Farese
May 16, 2001·Current Opinion in Lipidology·T Y ChangA Miyazaki
Sep 7, 2001·The Journal of Biological Chemistry·K K BuhmanR V Farese
Oct 26, 2001·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·S ElyR Kisilevsky
Oct 31, 2001·The Journal of Biological Chemistry·Xiaohui LuTa-Yuan Chang
Dec 18, 2001·Journal of Pharmaceutical Sciences·R Homan, K L Hamelehle
Nov 2, 2002·Nature Medicine·Peter Libby, Masanori Aikawa
Jan 23, 2003·Progress in Medicinal Chemistry·Drago R SliskovicBrian R Krause
Jan 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emily L WillnerRobert V Farese
May 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jasminder SahiEdward L LeCluyse
Jul 3, 2003·Journal of Lipid Research·Robert L Raffai, Karl H Weisgraber
Sep 19, 2003·Biochemical and Biophysical Research Communications·Kyung-Hyun ChoTae-Sook Jeong

❮ Previous
Next ❯

Citations

Aug 28, 2012·Pharmaceutical Research·Stephen D LeeKishor M Wasan
Feb 19, 2011·Current Atherosclerosis Reports·Xavier RoussetAlan T Remaley
Mar 4, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Antonella Mandas, Sandra Dessì
Jun 2, 2011·Chemical Reviews·Rosalind A Coleman, Douglas G Mashek
Jun 19, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Stephanie R MurphyTa-Yuan Chang
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Elena Y BrylevaTa-Yuan Chang
Apr 5, 2012·The Journal of Biological Chemistry·Maximillian A RogersTa-Yuan Chang
Nov 18, 2011·The Journal of Biological Chemistry·Dawn L Brasaemle, Nathan E Wolins
Feb 22, 2012·Cardiovascular Research·Sima AllahverdianGordon A Francis
Feb 1, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephen NesnowTanya Moore
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·Toyoshi Fujimoto, Robert G Parton
May 25, 2013·Annual Review of Nutrition·Kelly V RugglesStephen L Sturley
Sep 18, 2012·Journal of Lipid Research·Abraham YangSuleiman A Igdoura
Jul 20, 2012·Journal of Lipid Research·Chang Xie 谢畅Bao-Liang Song 宋保亮
Jan 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Bruno Ferraz-de-SouzaJohn C Achermann
Nov 30, 2013·Nutrients·Varsha Shete, Loredana Quadro
Nov 22, 2011·Future Medicinal Chemistry·Taichi Ohshiro, Hiroshi Tomoda
Jan 8, 2014·Iranian Red Crescent Medical Journal·Javad Zavar RezaMir Saeed Yekaninejad
Mar 1, 2014·International Journal of Molecular Sciences·Dong-Feng WuWu-Xian Chen
Aug 24, 2011·Journal of Electron Microscopy·Michitaka SuzukiToyoshi Fujimoto
May 15, 2012·Annual Review of Cell and Developmental Biology·Hector Alex Saka, Raphael Valdivia
Sep 13, 2012·Basic Research in Cardiology·Wim MartinetGuido R Y De Meyer
Feb 4, 2016·Human Gene Therapy·Sandro AlvesNathalie Cartier
Dec 17, 2015·Future Medicinal Chemistry·Yohei ShibuyaTa-Yuan Chang
Mar 20, 2016·Chemistry and Physics of Lipids·Vicky HoweAndrew J Brown
Mar 17, 2016·Nature·Michael L Dustin
Mar 30, 2016·Chemical & Pharmaceutical Bulletin·Yuichi MasudaTakayuki Doi
Sep 22, 2015·Frontiers in Pharmacology·Li-Hao HuangGwendalyn J Randolph

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.