Acylated ghrelin levels were associated with depressive status, physical quality of life, endoscopic findings based on Kyoto classification in Japan

Journal of Clinical Biochemistry and Nutrition
Shuhei AgawaKatsuhiko Iwakiri

Abstract

To determine whether serum acylated ghrelin levels were associated with anxiety, clinical symptoms, depressive status, quality of life, gastric motility and endoscopic findings based on Kyoto classification in functional dyspepsia (FD) patients. We enrolled three groups, FD patients (n = 15) with high levels of acylated ghrelin, FD patients (n = 33) with normal levels of acylated ghrelin and FD patients (n = 35) with low levels of acylated ghrelin. There was no significant differences in the positivity of Helicobacter pylori infection among the three groups. Clinical symptoms were evaluated by Gastrointestinal Symptom Rating Scale (GSRS) and FD symptoms based on Rome III classification. Acylated ghrelin levels were measured by ELISA methods. Depressive status, anxiety, sleep disturbance were respectively asscessed by Self-rating questionnaire for depression (SRQ-D) score, STAI-state/-trait, Pittsburgh sleep quality index (PSQI) scores. Endoscopic findings were evaluated based on Kyoto classification. Body Mass Index (BMI) in FD patients with low levels of acylated ghrelin was significantly higher (p<0.001 and p = 0.008, respectively) compared to those in FD patients with high and normal levels of acylated ghrelin. SRQ-D scores ...Continue Reading

References

Jul 1, 1969·Psychosomatics·B W Rockliff
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Tomomi ShiiyaShigeru Matsukura
May 23, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kwang-Jae LeeJan Tack
Jul 23, 2005·Scandinavian Journal of Gastroenterology·Toshiaki ShinomiyaYoshikatsu Nakai
Oct 20, 2005·Experimental Gerontology·Vishwa Deep Dixit, Dennis D Taub
May 9, 2006·Gastroenterology·Douglas A Drossman
May 16, 2006·Gastroenterology·Elena Gonzalez-ReyMario Delgado
Jul 25, 2006·Physiology & Behavior·David E Cummings
Jun 17, 2008·Nature Neuroscience·Michael LutterJeffrey M Zigman
Jul 1, 2008·Peptides·Xin-Yuan GaoHong Guo
Jul 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elisabet JerlhagJörgen A Engel
Aug 20, 2010·International Journal of Peptides·Jen-Chieh Chuang, Jeffrey M Zigman
Oct 14, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J KhooM Horowitz
Jan 29, 2011·BMC Gastroenterology·Chidi V Nweneka, Andrew M Prentice
Apr 25, 2013·World Journal of Gastroenterology : WJG·Celal UlasogluIlyas Tuncer
Apr 5, 2014·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Sachiyo NomuraUNKNOWN Research Group for Establishment of Endoscopic Diagnosis of Chronic Gastritis
Jul 19, 2015·Gut·Kentaro SuganoUNKNOWN faculty members of Kyoto Global Consensus Conference

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Citations

Apr 25, 2020·Biomolecules·Haba ElabadlahErnest A Adeghate
Feb 5, 2021·Journal of Clinical Biochemistry and Nutrition·Toshihiro NishizawaKazuhiko Koike

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