Acylated ghrelin treatment normalizes skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rat chronic heart failure

Journal of Cachexia, Sarcopenia and Muscle
R BarazzoniJochen Springer

Abstract

Chronic heart failure (CHF) is associated with skeletal muscle abnormalities contributing to exercise intolerance, muscle loss, and negative impact on patient prognosis. A primary role has been proposed for mitochondrial dysfunction, which may be induced by systemic and tissue inflammation and further contribute to low insulin signalling. The acylated form of the gastric hormone ghrelin (AG) may improve mitochondrial oxidative capacity and insulin signalling in both healthy and diseased rodent models. We investigated the impact of AG continuous subcutaneous administration (AG) by osmotic minipump (50 nmol/kg/day for 28 days) compared with placebo (P) on skeletal muscle mitochondrial enzyme activities, mitochondrial biogenesis regulators transcriptional expression and insulin signalling in a rodent post-myocardial infarction CHF model. No statistically significant differences (NS) were observed among the three group in cumulative food intake. Compared with sham-operated, P had low mitochondrial enzyme activities, mitochondrial biogenesis regulators transcripts, and insulin signalling activation at AKT level (P < 0.05), associated with activating nuclear translocation of pro-inflammatory transcription factor nuclear factor-κB. AG...Continue Reading

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Citations

Feb 6, 2018·Eating and Weight Disorders : EWD·Rocco BarazzoniEnzo Nisoli
Sep 5, 2018·Journal of Cachexia, Sarcopenia and Muscle·Magdalena DziegalaEwa Jankowska
Dec 21, 2018·ESC Heart Failure·Markus S AnkerUNKNOWN Heart Failure Association Cardio-Oncology Study Group of the European Society of Cardiology
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Oct 26, 2018·Eating and Weight Disorders : EWD·Gianluca Gortan Cappellari, Rocco Barazzoni
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Dec 15, 2018·ESC Heart Failure·Tsuyoshi SuzukiJochen Springer
Jun 15, 2019·Eating and Weight Disorders : EWD·Mahdieh Abbasalizad FarhangiZeinab Nikniaz
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Sep 12, 2020·International Journal of Molecular Sciences·Alessia LenaJochen Springer
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Dec 4, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Shingo TakadaShintaro Kinugawa

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Methods Mentioned

BETA
nuclear translocation
Protein Assay
ELISA

Software Mentioned

Primer Express

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