Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae)

Journal of Natural Medicines
Shin-Ichiro KurimotoYoshiki Kashiwada

Abstract

Twenty new neo-clerodane type diterpenoids, scutefolides G1-S (1-20), were isolated from the 70 % aqueous acetone extract of the aerial parts of Scutellaria coleifolia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of 1, 2, 7, 8, 14 and 15 were determined by means of the CD exciton chirality method. Compounds 1, 2, 5, 7, 8, 12, 14, 15, 18 and 19 were evaluated for their cytotoxic activities against four human cancer cell lines, and anti-bacterial activities against methicillin-resistant Staphylococcus aureus.

References

Apr 1, 1994·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Y MiyaichiT Tomimori
Jun 26, 2001·Journal of Natural Products·B EsquivelR A Toscano
Jan 28, 2005·Antimicrobial Agents and Chemotherapy·Hirofumi ShibataTomihiko Higuti
Sep 30, 2009·Journal of Natural Products·Sheng-Jun DaiYan Ren
Dec 8, 2009·Bioorganic & Medicinal Chemistry Letters·Hanna LeeSang Hee Shim
Jan 13, 2010·Journal of Ethnopharmacology·Xiaofei ShangZhengping Jia
Jan 19, 2010·Journal of Natural Products·Feng ZhuHong-Ping He
Sep 30, 2010·Phytochemistry·Rosa Angela RaccugliaMonique S J Simmonds
Feb 18, 2011·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Jinglei Xiao, Dacheng Jiang
Aug 13, 2015·Chemistry & Biodiversity·Shin-Ichiro KurimotoYoshiki Kashiwada

❮ Previous
Next ❯

Citations

Feb 10, 2018·Journal of Natural Medicines·Yoshihiro SuyamaYoshiki Kashiwada
Sep 7, 2017·Natural Product Reports·James R Hanson
Apr 4, 2017·Phytotherapy Research : PTR·Muhammad Torequl Islam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.