Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity

Bioorganic & Medicinal Chemistry Letters
Jeffrey M AxtenNino Campobasso

Abstract

A new class of PDF inhibitor with potent, broad spectrum antibacterial activity is described. Optimization of blood stability and potency provided compounds with improved pharmacokinetics that were suitable for in vivo experiments. Compound 5c, which has robust antibacterial activity, demonstrated efficacy in two respiratory tract infection models.

References

Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Sandhya Ramanathan-GirishKirk W Johnson

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Citations

Oct 21, 2016·Scientific Reports·Sonia FieulaineCarmela Giglione

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