AD8 Informant Questionnaire for Cognitive Impairment: Pragmatic Diagnostic Test Accuracy Study

Journal of Geriatric Psychiatry and Neurology
A J Larner

Abstract

The diagnostic accuracy of the AD8 informant questionnaire for cognitive impairment was assessed in patients referred to a dedicated memory clinic. This pragmatic prospective study of consecutive referrals attending with an informant who completed AD8 (n = 212) lasted 12 months. Diagnosis used standard clinical diagnostic criteria for dementia and mild cognitive impairment as reference standard (prevalence of cognitive impairment = 0.62). The AD8 proved acceptable to informants, was quick, and easy to use. Using the cutoff of ≥2/8, AD8 was highly sensitive (0.97) for diagnosis of cognitive impairment but specificity was poor (0.17). Combining AD8 with either the Mini-Mental State Examination or the Six-Item Cognitive Impairment Test showed little additional diagnostic benefit. In conclusion, AD8 is very sensitive for cognitive impairment in a memory clinic but specificity may be inadequate.

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Citations

Mar 5, 2019·The Cochrane Database of Systematic Reviews·Kirsty HendryTerry J Quinn
Oct 4, 2019·Neurodegenerative Disease Management·Andrew J Larner
May 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T M Liew
Oct 13, 2015·British Journal of Hospital Medicine·L St John, A J Larner
Aug 4, 2020·Annals of Geriatric Medicine and Research·Zeev MeinerJoe Verghese
Feb 9, 2017·International Journal of Geriatric Psychiatry·A J Larner
Jul 1, 2015·Dementia & Neuropsychologia·Antonio Eduardo DaminSonia Maria Dozzi Brucki
Dec 10, 2016·Age and Ageing·Jennifer Kirsty HarrisonSusan Deborah Shenkin
Jan 22, 2019·Journal of the American Medical Directors Association·Cheuk Ni KanXin Xu
Jul 19, 2021·Geriatric Nursing·Yan CaiWeihong Kuang
Jul 18, 2019·Dementia and Geriatric Cognitive Disorders·Andrew J Larner

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