Adalimumab effectively controls both anterior and posterior noninfectious uveitis associated with systemic inflammatory diseases: focus on Behçet's syndrome

Inflammopharmacology
Elena SilvestriDomenico Prisco

Abstract

To compare the efficacy of Adalimumab (ADA) in noninfectious anterior uveitis (AU) and posterior segment (PS) involvement, associated with different conditions, with a focus on Behçet's syndrome (BS). In this retrospective, multicenter post-hoc study, we evaluated the efficacy of ADA in terms of ocular control and relapses in 96 patients with AU and PS uveitis, either idiopathic (IU) or associated with BS or with other systemic disorders (OSD) (Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Vogt-Koyanagi-Harada, Inflammatory Bowel Disease), followed in three tertiary referral centers. Ninety-six patients (45 AU; 51 PS uveitis) were included. Eleven had IU, 58 BS, and 27 OSD. All patients with AU achieved complete long-term ocular control. In PS uveitis, 89%, 67% and 100% of patients with BS, IU and OSD achieved ocular control at the last follow-up (> 12 months), respectively. The lowest ocular relapse rate occurred in patients with AU with BS (1/13) or IU (0/2). ADA accounted for long-term disease control, and no predictors of ocular control and relapse were identified; particularly, ocular relapses seemed not related to systemic ones. Macular edema resolved in 75% and 67% of PS uveitis with BS and ...Continue Reading

References

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Jul 19, 2019·Internal and Emergency Medicine·Giacomo Emmi, Domenico Prisco

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Citations

Jul 24, 2020·Expert Review of Clinical Immunology·Carla GaggianoClaudia Fabiani
Feb 20, 2021·Journal of Experimental Pharmacology·Burçin Cansu Bozca, Erkan Alpsoy
Jun 2, 2021·American Journal of Clinical Dermatology·Erkan AlpsoyAsli Bilgic
May 18, 2021·Frontiers in Medicine·Erkan AlpsoyShigeaki Ohno
Jun 3, 2021·Journal of Clinical Medicine·Julie GueudryBahram Bodaghi

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