Adalimumab in pediatric Crohn's disease

Immunotherapy
Ashish S PatelJoel R Rosh

Abstract

Adalimumab, a human monoclonal antibody to tumor necrosis factor alpha (TNF-α), was initially approved for the treatment of moderate to severe rheumatoid arthritis in 2002. In the subsequent years, its anti-inflammatory properties were applied to the treatment of psoriatic arthritis, ankylosing spondylitis, adult Crohn's disease (CD), plaque psoriasis, polyarticular juvenile idiopathic arthritis, adult ulcerative colitis and most recently in 2014, pediatric CD. The biologic era in pediatric CD has changed and redefined the therapeutic approach to this challenging lifelong disease. This article summarizes the clinical legacy of adalimumab with a focus on its most recent expanded indication, pediatric CD.

References

Dec 25, 2008·Inflammatory Bowel Diseases·Jeffrey S HyamsUNKNOWN Pediatric Inflammatory Bowel Disease Collaborative Research Group
Sep 3, 2009·The American Journal of Gastroenterology·Joel R RoshJeffrey S Hyams
Dec 1, 2009·The Medical Clinics of North America·Cary G Sauer, Subra Kugathasan
Oct 5, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David S KotlyarGary R Lichtenstein
May 9, 2012·Gastroenterology·Jeffrey S HyamsAndreas Lazar
Aug 29, 2012·Digestive Diseases and Sciences·Michael D KappelmanSuzanne F Cook
Mar 6, 2013·Journal of Pediatric Gastroenterology and Nutrition·Jeremy AdlerGary L Freed
Apr 26, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Victoria GrossiJeffrey S Hyams

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Citations

Aug 31, 2017·World Journal of Gastroenterology : WJG·Graziella Guariso, Marco Gasparetto
Aug 22, 2020·Journal of the American Academy of Dermatology·Ellie ChoiNisha Suyien Chandran

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