ADAM17 protects against elastase-induced emphysema by suppressing CD62L+ leukocyte infiltration in mice

American Journal of Physiology. Lung Cellular and Molecular Physiology
Shoji SuzukiTomoko Betsuyaku

Abstract

Pulmonary emphysema is a major manifestation of chronic obstructive pulmonary disease and is associated with chronic pulmonary inflammation caused by cigarette smoking, with contributions from immune cells such as neutrophils, macrophages, and lymphocytes. Although matrix metalloproteinases are well-known to contribute to emphysema progression, the role of a disintegrin and metalloproteinase (ADAM) family proteins, other major metalloproteinases, in disease pathogenesis is largely unknown. ADAM17 is a major sheddase that cleaves various cell surface proteins, including CD62L, an adhesion molecule that plays a critical role in promoting the migration of immune cells to the site of inflammation. In the present study, we aimed to investigate the potential role of ADAM17 and CD62L in the development of elastase-induced emphysema. Eight-to-ten-week-old control and Adam17flox/flox/Mx1-Cre (Adam17ΔMx1) mice were intratracheally injected with 5 U of porcine pancreas elastase and monitored for 35 days after injection. Lung alveolar destruction was evaluated by analyzing the mean linear intercepts of lung tissue specimens and by histopathological examination. Mean linear intercepts data indicated that the degree of elastase-induced emphy...Continue Reading

References

Feb 1, 1995·The Journal of Experimental Medicine·K LeyA L Beaudet
Jun 1, 1995·The Journal of Experimental Medicine·T F TedderP Pizcueta
Sep 8, 1995·Science·R KühnK Rajewsky
Jun 1, 1997·Nature Medicine·G D Massaro, D Massaro
Dec 6, 2000·The Journal of Clinical Investigation·Y KasaharaN F Voelkel
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·M FujitaR J Mason
Jan 18, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Edgar C LuceyRonald H Goldstein
Nov 15, 2003·Immunity·Guglielmo M VenturiThomas F Tedder
Jun 9, 2004·American Journal of Respiratory and Critical Care Medicine·Andrew ChurgJoanne L Wright
Apr 9, 2005·Treatments in Respiratory Medicine·Suzanne J Romano
Feb 3, 2006·The European Respiratory Journal·A D LopezS Buist
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keisuke HoriuchiCarl P Blobel
Aug 28, 2007·Clinics in Chest Medicine·William Macnee
Feb 5, 2008·The Journal of Clinical Investigation·Laimute Taraseviciene-Stewart, Norbert F Voelkel
Jul 16, 2008·European Journal of Immunology·Makoto IshiiSteven L Kunkel
Jul 27, 2010·Experimental Lung Research·Sadatomo TasakaAkitoshi Ishizaka
Feb 8, 2011·American Journal of Respiratory Cell and Molecular Biology·Saleela M RuwanpuraBrendan J Jenkins
May 24, 2011·PloS One·Patrick G ArndtBruce Walcheck
Sep 17, 2011·The European Respiratory Journal·A ChurgJ L Wright
May 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Makoto IshiiTomoko Betsuyaku
Aug 12, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanna MarczynskaJoanna Cichy
Nov 14, 2015·The Journal of Infectious Diseases·Saeko TakahashiTomoko Betsuyaku
Jun 22, 2016·Nature Communications·C Colin BrinkmanJonathan S Bromberg
Jun 29, 2016·Critical Care Medicine·Kazuma YagiTomoko Betsuyaku
Jul 5, 2016·American Journal of Respiratory and Critical Care Medicine·Saleela M RuwanpuraBrendan J Jenkins
Dec 4, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Haruhiko YanagisawaStephen L Nishimura
Jun 21, 2017·Sleep & Breathing = Schlaf & Atmung·Stephan PramsohlerNikolaus Netzer
Jul 15, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Friederike Zunke, Stefan Rose-John
May 4, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hsin-Han HouChong-Jen Yu
May 12, 2018·American Journal of Respiratory and Critical Care Medicine·Francesca PolverinoCaroline A Owen
Jun 5, 2018·American Journal of Respiratory and Critical Care Medicine·Xiaoyun WangCaroline A Owen
Sep 23, 2018·Nature Reviews. Immunology·Bart N LambrechtHamida Hammad

❮ Previous
Next ❯

Citations

Nov 13, 2020·American Journal of Respiratory Cell and Molecular Biology·Mohamed I SaadBrendan J Jenkins
Apr 28, 2021·Biochemical and Biophysical Research Communications·Kentaro AonoAtsushi Yamauchi
Sep 16, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Satoshi OkamoriKoichi Fukunaga

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
bronchoalveolar lavage
bronchoalveolar
lavage
enzyme-linked immunosorbent assay
flow cytometry

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.