ADAMTS13 activity, high VWF and FVIII levels in the pathogenesis of deep vein thrombosis.

Thrombosis Research
Maria Teresa PagliariF Peyvandi

Abstract

Deep vein thrombosis (DVT) is a common multi-factorial disease with a partially understood aetiology. Although the roles of high factor (F)VIII and von Willebrand factor (VWF) levels are recognized, that of ADAMTS13 is still unclear. To assess the association between ADAMTS13 activity levels, VWF antigen (VWF:Ag) and FVIII coagulant activity (FVIII:C) levels and DVT. 365 Italian DVT patients and 292 age- and sex-matched controls were considered. Plasma ADAMTS13 activity was measured using FRETS-VWF73 assay. VWF:Ag and FVIII:C were measured using immunoassay and one-stage clotting assay (ACL TOP analyzer), respectively. Quartile analyses were performed to evaluate the individual association between ADAMTS13 activity, VWF:Ag, FVIII:C and DVT. The combined effect of high VWF levels (> 4th quartile) and low ADAMTS13 levels (< 1st quartile) was evaluated using binary variables. All models were age- and sex-adjusted. Estimated risks were reported as Odds ratio (OR) with 95% confidence intervals (CI). ADAMTS13 activity was lower in DVT patients (94% vs. 98% of controls). Patients with an ADAMTS13 activity <1st quartile (86%) showed a 1.6-fold increased risk of DVT (95%CI, 1.05-2.55). The combination of low ADAMTS13 activity and high V...Continue Reading

References

Aug 8, 2006·Journal of Thrombosis and Haemostasis : JTH·J E SadlerUNKNOWN Working Party on von Willebrand Disease Classification
Mar 20, 2008·JAMA : the Journal of the American Medical Association·Irene D BezemerFrits R Rosendaal
Mar 12, 2009·Cardiovascular & Hematological Disorders Drug Targets·Paul Coppo, Agnès Veyradier
Jul 9, 2009·Journal of Thrombosis and Haemostasis : JTH·Y LiF R Rosendaal
Jul 30, 2011·Journal of Thrombosis and Haemostasis : JTH·N A Zakai, L A McClure
Oct 4, 2012·Thrombosis Research·Bruna M MazettoJoyce M Annichino-Bizzacchi
Jun 16, 2015·Journal of Thrombosis and Haemostasis : JTH·A MainoF R Rosendaal
Aug 14, 2015·Journal of Thrombosis and Haemostasis : JTH·J F TimpS C Cannegieter
Nov 22, 2015·Journal of Thrombosis and Haemostasis : JTH·M PépinI Mahé
Aug 26, 2016·Journal of Thrombosis and Haemostasis : JTH·M A H SonneveldM P M de Maat
Oct 26, 2016·International Journal of Hematology·Yun FengSuhua Chen
Jul 12, 2017·Thrombosis Research·D LlobetJ C Souto
Nov 25, 2018·Journal of Thrombosis and Haemostasis : JTH·I M RietveldS C Cannegieter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.