ADAMTS13, lucky to have a hydrophobic pocket.

Blood
X Long Zheng

Abstract

In this issue of Blood, de Groot et al identify a hydrophobic pocket in the Cys-rich domain of ADAMTS13 that appears to interact with the hydrophobic pocket in the central A2 domain of von Willebrand factor (VWF) for its proteolysis.

References

Feb 24, 2009·Blood·Rens de GrootJames T B Crawley
Nov 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Masashi AkiyamaToshiyuki Miyata
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·X L Zheng
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kieron SouthDavid A Lane
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Joshua MuiaJ Evan Sadler
Jan 15, 2015·Annual Review of Medicine·X Long Zheng

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Citations

Jan 27, 2019·Journal of Biological Engineering·Shanshan YuJiangguo Lin

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