ADAMTS4 is upregulated in colorectal cancer and could be a useful prognostic indicator of colorectal cancer

Revista da Associação Médica Brasileira
Xue-Qin ShangJing Wu

Abstract

ADAMTS4 is a member of the ADAMTS4 family, which secretes proteinases. The mechanism of tumor metastasis may be correlated to its promotion of angiogenesis. It was determined whether ADAMTS4 participates in colorectal cancer progression. The expression in clinical samples and CRC cell lines was investigated. Using immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and RT-PCR, the expression of ADAMTS4 was determined in colorectal tumors of different cancer stages and anatomic sites, and in three cell lines of different aggressiveness. The overexpression of ADAMTS4 was observed in tissue samples by IHC, and this was mainly located in the cytoplasm, as detected by FISH. The qRT-PCR and western blot analyses further supported the clinical sample findings. The present data support the notion that the overexpression of ADAMTS4 in CRC might be useful as a non-invasive biomarker for detecting CRC in patients.

References

Jul 9, 2005·International Journal of Cancer. Journal International Du Cancer·Janka Held-FeindtRolf Mentlein
Jan 5, 2011·Protein & Cell·Edward A Lin, Chuan-Ju Liu
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 16, 2013·International Journal of Cancer. Journal International Du Cancer·Nithya RaoRuowen Ge
Nov 2, 2013·Journal of Neuroinflammation·Sighild LemarchantJari Koistinaho
May 16, 2014·Nature Reviews. Cancer·Daniele M GilkesDenis Wirtz
Jun 20, 2014·World Journal of Gastroenterology : WJG·Gemma BinefaManuel Medina-Hayas
Nov 10, 2014·EMBO Reports·Michael W PickupValerie M Weaver
Dec 6, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Rosalia LeonardiCarla Loreto
Feb 1, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Santiago Cal, Carlos López-Otín
Mar 19, 2015·PloS One·Serafula FilouDemitrios H Vynios
Jun 18, 2016·Science·Wendy V GilbertCassandra Schaening
Jan 14, 2017·Journal of Neuroscience Research·Sighild LemarchantJari Koistinaho
Apr 26, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jianjun ChenMing Zhong

❮ Previous
Next ❯

Citations

Mar 16, 2021·Matrix Biology Plus·Silvia Redondo-GarcíaJuan Carlos Rodríguez-Manzaneque

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Jianjun ChenMing Zhong
Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yanping ZhaLianqun Cui
© 2021 Meta ULC. All rights reserved