ADAPT: An Algorithm Incorporating PRO-C3 Accurately Identifies Patients With NAFLD and Advanced Fibrosis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Samuel J DanielsJacob George

Abstract

Given the high global prevalence of nonalcoholic fatty liver disease (NAFLD), the need for relevant noninvasive biomarkers and algorithms to accurately stage disease severity is a critical unmet medical need. Identifying those with advanced fibrosis (≥ F3) is the most crucial, as these individuals have the greatest risk of adverse, long-term, liver-related outcomes. We aimed to investigate the role of PRO-C3 (a marker of type III collagen formation) as a biomarker for advanced fibrosis in NAFLD. We measured PRO-C3 by enzyme-linked immunosorbent assay in two large independent cohorts with extensive clinical phenotyping and liver biopsy: 150 in the derivation and 281 in the validation cohort. A PRO-C3-based fibrosis algorithm that included age, presence of diabetes, PRO-C3, and platelet count (ADAPT) was developed. PRO-C3 increased with fibrosis stage (Rho 0.50; P < 0.0001) and was independently associated with advanced fibrosis (odds ratio = 1.05; 95% confidence interval [CI] 1.02-1.08; P = 0.003). ADAPT showed areas under the receiver operating characteristics curve of 0.86 (95% CI 0.79-0.91) in the derivation and 0.87 in the validation cohort (95% CI 0.83-0.91) for advanced fibrosis. This was superior to the existing fibrosis ...Continue Reading

References

Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AnguloK D Lindor
Jun 2, 2000·Gastroenterology·V RatziuT Poynard
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier FornsJuan Rodés
Oct 19, 2002·The American Journal of Gastroenterology·Arie RegevEugene R Schiff
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pouneh MofradArun J Sanyal
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jun 9, 2005·Gastroenterology·Vlad RatziuUNKNOWN LIDO Study Group
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Aug 8, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Toshio FukusatoUNKNOWN Liver Disease Working Group-Kanto
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
Sep 10, 2008·Journal of Clinical Epidemiology·Mariska M G LeeflangLes Irwig
Jun 16, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amy G ShahUNKNOWN Nash Clinical Research Network
Jan 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laurent CastéraVictor de Lédinghen
Mar 2, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiZachary Goodman
Sep 29, 2011·Journal of Gastroenterology and Hepatology·Leon A AdamsGary P Jeffrey
Aug 30, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sudeep TanwarWilliam M Rosenberg
Oct 18, 2013·QJM : Monthly Journal of the Association of Physicians·Matthew J ArmstrongJeremy W Tomlinson
May 7, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Salvatore PettaAntonio Craxì
Aug 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtRolf Hultcrantz
Oct 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Mette J NielsenKeyur Patel
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver, UNKNOWN Asociacion Latinoamericana para el Estudio del Higado
Nov 26, 2015·Journal of Hepatology·Mohammed EslamUNKNOWN International Liver Disease Genetics Consortium (ILDGC)
Apr 12, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL)UNKNOWN European Association for the Study of Obesity (EASO)
Apr 23, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Konstantin KazankovHenning Grønbaek
Oct 12, 2016·The American Journal of Gastroenterology·Stuart McPhersonQuentin M Anstee
Oct 22, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Morten A KarsdalDetlef Schuppan
Sep 21, 2017·Nature Reviews. Gastroenterology & Hepatology·Zobair YounossiElisabetta Bugianesi

❮ Previous
Next ❯

Citations

Oct 6, 2018·Alimentary Pharmacology & Therapeutics·Christian LabenzJörn M Schattenberg
Nov 30, 2018·Alimentary Pharmacology & Therapeutics·Christian Labenz, Jörn M Schattenberg
Dec 6, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jörn M Schattenberg, Rohit Loomba
Jul 26, 2019·Alimentary Pharmacology & Therapeutics·Yvonne HuberJörn M Schattenberg
Aug 23, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Antonella MoscaGiovanni Targher
Jan 31, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Morten A KarsdalDetlef Schuppan
Jan 7, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Samuel J DanielsSimon Cruwys
Feb 19, 2020·Gut·Rohit Loomba, Leon A Adams
Jan 17, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vlad RatziuFrank Tacke
Mar 29, 2019·World Journal of Gastroenterology : WJG·Jiang-Hua ZhouHong-Liang Li
Mar 13, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cyrielle CaussyRohit Loomba
Oct 8, 2019·Expert Review of Gastroenterology & Hepatology·J H MortensenT Manon-Jensen
Jan 15, 2020·Pharmaceutical Medicine·Somaya Albhaisi, Arun J Sanyal
May 19, 2020·Alimentary Pharmacology & Therapeutics·Ida Falk VillesenMette Juul Nielsen
Sep 29, 2020·Hepatic Medicine : Evidence and Research·Marten Schulz, Frank Tacke
Jun 4, 2020·International Journal of Molecular Sciences·Hideki Fujii Japan Study Group Of Nafld Jsg-Nafld
Oct 24, 2019·Nature Reviews. Gastroenterology & Hepatology·Mohammed Eslam, Jacob George
Nov 20, 2019·Nature Reviews. Gastroenterology & Hepatology·Christopher D Byrne, Giovanni Targher
May 27, 2020·Journal of Gastroenterology·Janae Wentong WaiVincent Wai-Sun Wong
Sep 16, 2020·Chinese Medical Journal·Rafael S RiosMing-Hua Zheng
Dec 9, 2020·Zeitschrift für Gastroenterologie·Maurice Michel, Jörn M Schattenberg
Jun 12, 2020·Seminars in Liver Disease·Leon A Adams, Wah-Kheong Chan
Dec 29, 2020·Molecular Metabolism·Brian FinanBin Yang
Jan 20, 2021·BMJ : British Medical Journal·Maria Letizia PetroniGiulio Marchesini
Nov 24, 2020·JHEP Reports : Innovation in Hepatology·Mette VesterhusDouglas Thorburn
Oct 27, 2020·Endocrinology, Diabetes & Metabolism·Jose Hernandez Roman, Mohammad S Siddiqui
Feb 15, 2021·Clinical Therapeutics·Shannon Kogachi, Mazen Noureddin
Jul 9, 2020·JHEP Reports : Innovation in Hepatology·Gavin E Arteel, Alexandra Naba
Apr 16, 2021·Journal of Hepatocellular Carcinoma·Daniel GehHelen L Reeves
Apr 25, 2021·Lancet·Elizabeth E PowellMary Rinella

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Konstantin KazankovHenning Grønbaek
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Amy G ShahNash Clinical Research Network
BMC Gastroenterology
Yoshio SumidaJapan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Samiullah ShaikhKhalid Shaikh
Liver International : Official Journal of the International Association for the Study of the Liver
Sae Kyung JooByeong Gwan Kim
© 2022 Meta ULC. All rights reserved