The pervasive influence of temperature on biological systems necessitates a suite of temperature--compensatory adaptations that span all levels of biological organization--from behavior to fine-scale molecular structure. Beginning about 50 years ago, physiological studies conducted with whole organisms or isolated tissues, by such pioneers of comparative thermal physiology as V.Ya. Alexandrov, T.H. Bullock, F.E.J. Fry, H. Precht, C.L. Prosser, and P.F. Scholander, began to document in detail the abilities of ectothermic animals to sustain relatively similar rates of metabolic activity at widely different temperatures of adaptation or acclimation. These studies naturally led to investigation of the roles played by enzymatic proteins in metabolic temperature compensation. Peter Hochachka's laboratory became an epicenter of this new focus in comparative physiology. The studies of the enzyme lactate dehydrogenase (LDH) that he initiated as a PhD student at Duke University in the mid-1960s and continued for several years at the University of British Columbia laid much of the foundation for subsequent studies of protein adaptation to temperature. Studies of orthologs of LDH have revealed the importance of conserving kinetic propertie...Continue Reading
Interrelations between pH and temperature for the catalytic rate of the M4 lsozyme of lactate dehydrogenase (EC 126.96.36.199) from goldfish (Carassius auratus L.)
Turnover of cytochrome C in skeletal muscle of green sunfish (Lepomis cyanellus, R.) during thermal acclimation
Temperature adaptation of enzymes: a proposed molecular basis for the different catalytic efficiencies of enzymes from ectotherms and endotherms
Temperature adaptation of enzymes: roles of the free energy, the enthalpy, and the entropy of activation
Enzymes in facultative anaerobiosis of molluscs. II. Basic catalytic properties of phosphoenolpyruvate carboxykinase in oyster adductor muscle
Functional significance of isoenzymes in thermal acclimatization. Acetylcholinesterase from trout brain
Isoenzymes in metabolic adaptation of a poikilotherm: subunit relationships in lactic dehydrogenases of goldfish
Source of catalysis in the lactate dehydrogenase system. Ground-state interactions in the enzyme-substrate complex
Hot spots in cold adaptation: localized increases in conformational flexibility in lactate dehydrogenase A4 orthologs of Antarctic notothenioid fishes
Intrinsic versus extrinsic stabilization of enzymes: the interaction of solutes and temperature on A4-lactate dehydrogenase orthologs from warm-adapted and cold-adapted marine fishes
Unusual organic osmolytes in deep-sea animals: adaptations to hydrostatic pressure and other perturbants
Physiological and biochemical adaptation of goldfish to cold and warm temperatures. II. Oxygen consumption of liver homogenate; oxygen consumption and oxidative phosphorylation of liver mitochondria
Evolutionary convergence in adaptation of proteins to temperature: A4-lactate dehydrogenases of Pacific damselfishes (Chromis spp.)
Protein adaptations to temperature and pressure: complementary roles of adaptive changes in amino acid sequence and internal milieu
Changes in gene expression associated with acclimation to constant temperatures and fluctuating daily temperatures in an annual killifish Austrofundulus limnaeus
The relation of the central nervous system to the increase in systemic flow produced by occlusion of the thoracic aorta
High contents of trimethylamine oxide correlating with depth in deep-sea teleost fishes, skates, and decapod crustaceans
Joint effect of phosphorus limitation and temperature on alkaline phosphatase activity and somatic growth in Daphnia magna.
Different environmental temperatures affect amino acid metabolism in the eurytherm teleost Senegalese sole (Solea senegalensis Kaup, 1858) as indicated by changes in plasma metabolites
Pressure-adaptive differences in lactate dehydrogenases of three hagfishes: Eptatretus burgeri, Paramyxine atami and Eptatretus okinoseanus
Behavioural, ventilatory and respiratory responses of epigean and hypogean crustaceans to different temperatures
Protein cold adaptation strategy via a unique seven-amino acid domain in the icefish (Chionodraco hamatus) PEPT1 transporter
Genome evolution in the cold: Antarctic icefish muscle transcriptome reveals selective duplications increasing mitochondrial function
Proteomics to assess the role of phenotypic plasticity in aquatic organisms exposed to pollution and global warming
Functional determinants of temperature adaptation in enzymes of cold- versus warm-adapted mussels (Genus Mytilus)
The PAS/LOV protein VIVID controls temperature compensation of circadian clock phase and development in Neurospora crassa
Molecular identification of differentially regulated genes in the hydrothermal-vent species Bathymodiolus thermophilus and Paralvinella pandorae in response to temperature
Evolutionary force in confamiliar marine vertebrates of different temperature realms: adaptive trends in zoarcid fish transcriptomes
Cold acclimation increases mitochondrial oxidative capacity without inducing mitochondrial uncoupling in goldfish white skeletal muscle
Functional and structural characterization of a eurytolerant calsequestrin from the intertidal teleost Fundulus heteroclitus
Variation in thermal sensitivity and thermal tolerances in an invasive species across a climatic gradient: lessons from the land snail Cornu aspersum
The thermal tolerance of crayfish could be estimated from respiratory electron transport system activity
Effects of cold acclimation and storage temperature on crucian carp (Carassius auratus gibelio) in a waterless preservation
Transcriptional responses to temperature and low oxygen stress in Atlantic salmon studied with next-generation sequencing technology
Acclimation of Solea senegalensis to different ambient temperatures: implications for thyroidal status and osmoregulation.
Sorbitol counteracts temperature- and chemical-induced denaturation of a recombinant α-amylase from alkaliphilic Bacillus sp. TS-23
Teleost fish models in membrane transport research: the PEPT1(SLC15A1) H+-oligopeptide transporter as a case study
Copper levels and changes in pH induce oxidative stress in the tissue of curimbata (Prochilodus lineatus)
Keeping your options open: Maintenance of thermal plasticity during adaptation to a stable environment
Seasonal variations of cellular stress response in the heart and gastrocnemius muscle of the water frog (Pelophylax ridibundus)
Starch supplementation modulates amylase enzymatic properties and amylase B mRNA level in the digestive gland of the Pacific oyster Crassostrea gigas
The importance of physiological limits in determining biogeographical range shifts due to global climate change: the heat-shock response
Long-term warm or cold acclimation elicits a specific transcriptional response and affects energy metabolism in zebrafish
Interactive effects of environmental salinity and temperature on metabolic responses of gilthead sea bream Sparus aurata
Pituitary gene and protein expression under experimental variation on salinity and temperature in gilthead sea bream Sparus aurata
Defying the activity-stability trade-off in enzymes: taking advantage of entropy to enhance activity and thermostability
Molecular cold-adaptation of protein function and gene regulation: The case for comparative genomic analyses in marine ciliated protozoa
Microscopic rate-constants for substrate binding and acylation in cold-adaptation of trypsin I from Atlantic cod
Enzymatic characterization of recombinant α-amylase in the Drosophila melanogaster species subgroup: is there an effect of specialization on digestive enzyme?
Fish pre-acclimation temperature only modestly affects cadmium toxicity in Atlantic salmon hepatocytes
Effect of copper on liver key enzymes of anaerobic glucose metabolism from freshwater tropical fish Prochilodus lineatus.
Engineered disulfide bonds increase active-site local stability and reduce catalytic activity of a cold-adapted alkaline phosphatase
Nature's inordinate fondness for metabolic enzymes: why metabolic enzyme loci are so frequently targets of selection
Gene expression profile in the liver of Rana catesbeiana tadpoles exposed to low temperature in the presence of thyroid hormone
Could the acid-base status of Antarctic sea urchins indicate a better-than-expected resilience to near-future ocean acidification?
Molecular insights into cold active polygalacturonase enzyme for its potential application in food processing
Effects of feed restriction on the upper temperature tolerance and heat shock response in juvenile green and white sturgeon
Aerobic and anaerobic energy production in juvenile roach (Rutilus rutilus): regulation of glycolytic process by ethofumesate at two temperatures
Temperature dependence of in vitro Rubisco kinetics in species of Flaveria with different photosynthetic mechanisms
Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism
A New APEH Cluster with Antioxidant Functions in the Antarctic Hemoglobinless Icefish Chionodraco hamatus
Conserved and unique thermodynamic properties of lactate dehydrogenases in an ectothermic organism, the teleost Microstomus achne, and an endothermic organism, bovine
Imbalanced nutrient recycling in a warmer ocean driven by differential response of extracellular enzymatic activities
Serine hydroxymethyltransferase from the cold adapted microorganism Psychromonas ingrahamii: a low temperature active enzyme with broad substrate specificity
Structural analyses of adenylate kinases from Antarctic and tropical fishes for understanding cold adaptation of enzymes
Evaluating the role of NRF-1 in the regulation of the goldfish COX4-1 gene in response to temperature
Thermal biology of the sub-polar-temperate estuarine crab Hemigrapsus crenulatus (Crustacea: Decapoda: Varunidae)
Effects of elevated temperature on osmoregulation and stress responses in Atlantic salmon Salmo salar smolts in fresh water and seawater
Key amino acid residues conferring enhanced enzyme activity at cold temperatures in an Antarctic polyextremophilic β-galactosidase
Comparative proteomics of stenotopic caddisfly Crunoecia irrorata identifies acclimation strategies to warming
Control of the glycolytic flux in Saccharomyces cerevisiae grown at low temperature: a multi-level analysis in anaerobic chemostat cultures
Effect of early thermal environment on the morphology and performance of a lizard species with bimodal reproduction
A novel multicopper oxidase (laccase) from cyanobacteria: Purification, characterization with potential in the decolorization of anthraquinonic dye
Effect of pH on temperature controlled degradation of reactive oxygen species, heat shock protein expression, and mucosal immunity in the sea cucumber Isostichopus badionotus
Structural and mutational analyses of psychrophilic and mesophilic adenylate kinases highlight the role of hydrophobic interactions in protein thermal stability
High-throughput quantification of protein structural change reveals potential mechanisms of temperature adaptation in Mytilus mussels
Substrate regulation leads to differential responses of microbial ammonia-oxidizing communities to ocean warming
Purification and properties of glutathione reductase from liver of the anoxia-tolerant turtle, Trachemys scripta elegans
The molecular basis of aerobic metabolic remodeling differs between oxidative muscle and liver of threespine sticklebacks in response to cold acclimation
Uncommon functional properties of the first piscine 26S proteasome from the Antarctic notothenioid Trematomus bernacchii
Living on the Edge: Physiological and Kinetic Trade-Offs Shape Thermal Tolerance in Intertidal Crabs From Tropical to Sub-Antarctic South America
Delineating Substrate Diversity of Disparate Short-Chain Dehydrogenase Reductase from Debaryomyces hansenii
Structural and functional insights into TRiC chaperonin from a psychrophilic yeast, Glaciozyma antarctica
Metabolic plasticity in development: Synergistic responses to high temperature and hypoxia in zebrafish, Danio rerio
Biochemical adaptation in brain Acetylcholinesterase during acclimation to sub-lethal temperatures in the eurythermal fish Tilapia mossambica
Salinity modulates thermotolerance, energy metabolism and stress response in amphipods Gammarus lacustris
Adjustments of cardiac mitochondrial phenotype in a warmer thermal habitat is associated with oxidative stress in European perch, Perca fluviatilis.
Different amplitudes of temperature fluctuation induce distinct transcriptomic and metabolomic responses in the dung beetle Phanaeus vindex.
High thermal stress responses of Echinolittorina snails at their range edge predict population vulnerability to future warming
Acute environmental temperature variation affects brain protein expression, anxiety and explorative behaviour in adult zebrafish.
Identification of Stress-Related Genes and a Comparative Analysis of the Amino Acid Compositions of Translated Coding Sequences Based on Draft Genome Sequences of Antarctic Yeasts.
The osmotic response capacity of the Antarctic fish Harpagifer antarcticus is insufficient to cope with projected temperature and salinity under climate change.
Temperature adaptations of the thermophilic snail Echinolittorina malaccana: insights from metabolomic analysis.
Proteomic comparison between two marine snail ecotypes reveals details about the biochemistry of adaptation
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