Adaptation of human pineal melatonin suppression by recent photic history

The Journal of Clinical Endocrinology and Metabolism
Kurt A SmithCharles A Czeisler

Abstract

The human circadian pacemaker controls the timing of the release of the pineal hormone melatonin, which promotes sleep, decreases body temperature, and diminishes cognitive performance. Abnormal melatonin secretion has been observed in psychiatric and circadian disorders. Although melatonin secretion is directly suppressed by exposure to light in a nonlinear intensity-dependent fashion, little research has focused on the effect of prior photic history on this response. We examined eight subjects in controlled laboratory conditions using a within-subjects design. Baseline melatonin secretion was monitored under constant routine conditions and compared with two additional constant routines with a fixed light stimulus for 6.5 h of 200 lux (50 microW/cm(2)) after approximately 3 d of photic exposure during the subjective day of either about 200 lux (50 microW/cm(2)) or about 0.5 lux (0.15 microW/cm(2)). We found a significant increase in melatonin suppression during the stimulus after a prior photic history of approximately 0.5 lux compared with approximately 200 lux, revealing that humans exhibit adaptation of circadian photoreception. Such adaptation indicates that translation of a photic stimulus into drive on the human circadia...Continue Reading

Citations

Jun 2, 2007·Breast Cancer Research and Treatment·V SrinivasanG J Maestroni
Apr 6, 2006·Cancer Causes & Control : CCC·Samar A JasserGeorge C Brainard
Jul 10, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Catherine BeaulieuPierre Lachapelle
Sep 29, 2009·Reviews in Endocrine & Metabolic Disorders·Melanie Rüger, Frank A J L Scheer
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·A J Lewy
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·C A Czeisler, J J Gooley
May 14, 2010·Science Translational Medicine·Joshua J GooleySteven W Lockley
Sep 2, 2008·The British Journal of Ophthalmology·P L Turner, M A Mainster
Mar 30, 2010·Journal of Biological Rhythms·Karine ScheuermaierJeanne F Duffy
May 21, 2010·Journal of Biological Rhythms·Christopher M JungKenneth P Wright
Aug 12, 2006·Journal of Carcinogenesis·Mariana G FigueiroJohn D Bullough
May 12, 2005·The Journal of Clinical Endocrinology and Metabolism·Helen J Burgess, Charmane I Eastman
Jan 5, 2011·The Journal of Clinical Endocrinology and Metabolism·Joshua J GooleySteven W Lockley
Aug 9, 2007·PloS One·Frank A J L ScheerCharles A Czeisler
Apr 4, 2014·PloS One·Kathryn J ReidPhyllis C Zee
Sep 30, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lily YanRae Silver
Jun 4, 2011·Journal of Physiological Anthropology·Tomoaki KozakiAkira Yasukouchi
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Claude GronfierCharles A Czeisler
Aug 18, 2012·International Journal of Endocrinology·Mariana G Figueiro, Mark S Rea
Apr 11, 2009·Chronobiology International·Jonathan S EmensAlfred J Lewy
Apr 25, 2012·The Journal of Physiology·Anne-Marie ChangCharles A Czeisler
May 2, 2012·The Journal of Physiology·Melissa A St HilaireSteven W Lockley
Oct 23, 2013·The Journal of Physiology·Seong Jae KimPhyllis C Zee
Jan 13, 2011·The Journal of Physiology·Anne-Marie ChangCharles A Czeisler
Feb 18, 2010·Sleep Medicine Clinics·Jeanne F Duffy, Charles A Czeisler
Jul 1, 2008·Epilepsy & Behavior : E&B·Wytske A Hofstra, Al W de Weerd
Oct 16, 2007·Sleep Medicine Reviews·Christian Cajochen
Apr 10, 2007·Cancer Detection and Prevention·Regina P DopfelEva S Schernhammer
Mar 27, 2007·Sleep Medicine·Stephanie J CrowleyMary A Carskadon
Mar 27, 2007·Sleep Medicine·Marie Dumont, Catherine Beaulieu
Nov 3, 2011·Journal of Advanced Nursing·Shao-Yu TsaiKathryn E Barnard
Apr 20, 2006·Neurobiology of Aging·Jeanne F DuffyCharles A Czeisler
Oct 12, 2005·Brain Research. Brain Research Reviews·Mark S ReaAndrew Bierman

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