PMID: 6108122Nov 1, 1980Paper

Adaptation of hypertensives to treatment with cardioselective and non-selective beta-blockers. Absence of correlation between bradycardia and blood pressure control, and reduction in slope of the QT/RR relation

British Heart Journal
E M WilliamsJ V Jones

Abstract

Thirty mild hypertensives were treated for more than two months with either cardioselective (atenolol or metoprolol) or non-selective (propranolol or pindolol) beta-blockers; the patients were assigned to the drugs in a double-blind manner. A procedure was designed to distinguish between the effects of the drugs themselves while treatment continued, and the development of adaptive changes which would persist when the drugs had been eliminated from the body. Though individual responses to treatment varied in both groups, the mean effect of the cardioselective and non-selective drugs in the control of hypertension was similar. There was no evidence of the development of supersensitivity or "rebound". On the contrary, an adaptive bradycardia (that is a fall of not less than 10% in heart rate persisting 52 hours after stopping treatment) was observed at rest in 17/30 patients, and peak heart rates and blood pressures during exercise were lower in both groups than before treatment. Cardioselective drugs induced a significantly greater bradycardia at rest than non-selective, but on exercise increases in heart rate were reduced more by the non-selective drugs, so that the same peak heart rates were reached on exercise in both groups. ...Continue Reading

References

Nov 1, 1976·Clinical Pharmacology and Therapeutics·H C BrownR G Shanks
Jul 9, 1977·British Medical Journal·A E Raine, T G Pickering
Sep 1, 1979·Journal of Cardiovascular Pharmacology·P Lund-Johansen
Jan 9, 1975·The New England Journal of Medicine·E L BravoH P Dustan
Aug 1, 1975·Clinical Pharmacology and Therapeutics·J A Franciosa, E D Freis
Feb 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T ReybrouckL Billiet
Jan 12, 1974·British Medical Journal·G S StokesI R Thornell
Feb 1, 1972·The Journal of Clinical Endocrinology and Metabolism·A M Michelakis, R G McAllister
May 1, 1973·British Heart Journal·P A MajidS H Taylor
Jun 8, 1968·British Medical Journal·G S Humphreys, D G Delvin
Feb 21, 1970·British Medical Journal·F J Zacharias, K J Cowen
Aug 1, 1970·British Journal of Pharmacology·B N Singh, E M Vaughan Williams
Apr 1, 1970·The Journal of Physiology·A S FreedbergE M Williams
Jan 4, 1969·British Medical Journal·B N PRICHARD, P M GILLAM
Jan 1, 1980·British Heart Journal·J R MilneR A Spurrell
May 9, 1964·British Medical Journal·B N PRICHARD
Sep 19, 1964·British Medical Journal·B N PRICHARD, P M GILLAM

Citations

Apr 1, 1983·Pediatric Cardiology·H B Burchell
Mar 1, 1995·Journal of Advanced Nursing·P Castelein, J R Kerr
Feb 26, 1983·British Medical Journal·R M DonaldsonA F Rickards
Jun 1, 1982·British Heart Journal·E M Vaughan Williams
May 1, 1985·Postgraduate Medical Journal·R A Kenny, R Sutton
Nov 1, 1983·Pacing and Clinical Electrophysiology : PACE·R M Donaldson, A F Rickards
Apr 1, 1984·Journal of Clinical Pharmacology·E M Vaughan Williams
Jun 1, 1982·British Journal of Clinical Pharmacology·R G Wilcox, J R Hampton
Feb 3, 2015·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Ricardo A QuinteiroHoracio J Casabe
Dec 6, 2005·Angiology·S AlexiouA Deligiannis
Mar 1, 1983·Pacing and Clinical Electrophysiology : PACE·R M Donaldson, A F Rickards

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.