Adaptation of jejunal to colonic mucosal autografts in experimentally induced short bowel syndrome

Digestive Diseases and Sciences
A K BanerjeeT J Peters

Abstract

The behavior of jejunal to colonic mucosal autografts was studied in an experimental animal model of short bowel syndrome (SBS). Histological appearances, enterocyte enzyme activities, and in vitro glucose transport were studied at the donor and recipient graft sites in control, short-bowel syndrome, and gastrocolic fistula 5-week-old Sprague-Dawley rats. Small intestinal function was maintained in the jejunocolonic graft after 80% small bowel resection; animals in which small bowel was not resected showed loss of graft function and enzyme activity. This effect is dependent on the presence of jejunal chyme: after gastrocolic fistulae, the jejunum to colon grafts lost jejunal functional activities. Total parenteral nutrition did not alter graft behavior but improved the postoperative mortality of the procedures. The results provide additional information on intestinal adaptation in SBS.

References

Jun 22, 1978·The New England Journal of Medicine·R C Williamson
Jul 1, 1979·The British Journal of Surgery·A A Barros D'Sa
Oct 1, 1985·Pediatric Clinics of North America·M Z Schwartz, K Maeda
Mar 1, 1972·Archives of Surgery·E SteigerS J Dudrick
Oct 1, 1973·Journal of Pediatric Surgery·H B BinningtonJ L Ternberg
Mar 1, 1972·American Journal of Surgery·J O RuizR C Lillehei
Oct 1, 1982·The British Journal of Surgery·A K LiC G Jamieson
Apr 1, 1984·The Journal of Surgical Research·J S ThompsonP E Hodgson
Nov 1, 1980·The Journal of Surgical Research·E GatonB Man
May 1, 1982·Archives of Surgery·T R WeberJ L Grosfeld
May 1, 1981·American Journal of Surgery·G A López-PérezC Miguelez
Mar 1, 1980·The Journal of Surgical Research·L C WatsonP W Mellick
Oct 1, 1980·The Surgical Clinics of North America·M D Tilson
May 1, 1957·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M M NACHLASA M SELIGMAN

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