Adaptation of methicillin-resistant Staphylococcus aureus during antibiotic therapy

The Journal of Antimicrobial Chemotherapy
R E MenziesD MacCulloch

Abstract

Colonization of a patient by methicillin-resistant Staphylococcus aureus (MRSA) of a single phage-type for over four years is described. During this period we observed the appearance and disappearance of resistance to erythromycin, clindamycin, gentamicin, kanamycin, tobramycin, neomycin and mupirocin. We also saw stepwise increases in methicillin resistance and reversible changes in physical appearance and the colonizer pathogen role. Correlation of clinical observations, details of antibiotic therapy and laboratory studies demonstrated that adaptation of MRSA during antibiotic therapy favoured MRSA establishment and predominance.

Citations

Mar 21, 2000·International Journal of Antimicrobial Agents·M Y RohaniT Zainuldin
Dec 1, 1991·Journal of Clinical Pharmacy and Therapeutics·H J Eadon, R J Pinney
Feb 20, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A T AndrasevicG L French
Jul 23, 2013·Applied and Environmental Microbiology·Krunal K MehtaRavi S Kane
Jan 1, 1991·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·M E Mulligan, R D Arbeit

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