Adaptation of rat soleus muscle spindles after 21 days of hindlimb unloading

Experimental Neurology
Cédric RosantC Pérot

Abstract

Spindle discharges are affected by muscle unloading, and changes in passive stiffness of the muscle-tendon unit may contribute to the changes in spindle solicitation. To test this hypothesis, we determined the spindle sensitivity from electroneurograms of the soleus nerve, and, concomitantly, we measured the incremental passive muscle tension. Both measurements were done from ramp and hold stretches imposed to the soleus muscle after the Achilles tendon was severed. The ratio between the spindle sensitivity and the passive stiffness gave a "spindle efficacy index" (SEI). The experiments were conducted on control rats (C, n = 12) and on rats that had undergone hindlimb unloading (HU, n = 12) for 21 days. The muscle threshold lengths for electroneurogram to discharge (neurogram length, Ln) and for detecting passive tension (slack length, Ls) were determined, and, when these lengths differed, the stretches were imposed at these two initial lengths. The contralateral muscles were used to count muscle spindles and spindle fibers (ATPase staining) and to identify MyHC isoforms by immunostaining. Ln and Ls values were identical for the C muscles, while after HU, Ln was significantly shorter than Ls, which indicated that spindle affere...Continue Reading

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Citations

Nov 23, 2006·Experimental Gerontology·Cédric RosantChantal Pérot
Jul 28, 2010·Journal of Muscle Research and Cell Motility·Xue Hong ZhaoMing Xia Chen
Mar 10, 2007·Journal of Applied Physiology·Jean-Francois GrossetChantal Pérot

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