PMID: 15230487Jul 3, 2004Paper

Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications

Vascular Medicine
Scott M Wasserman, James N Topper

Abstract

Biomechanical forces generated by blood flow play an important role in the pathogenesis of vascular disease. For example, regions exposed to non-uniform shear stresses develop early atherosclerotic lesions while areas exposed to uniform shear stresses are protected. A variety of in vitro flow apparatuses have been created to apply well-characterized flow patterns to endothelial cells in an effort to dissect the cellular and molecular pathways involved in these distinct processes. Recent advances in biotechnology have permitted large-scale transcriptional profiling techniques to replace candidate gene screens and have allowed the genome-wide examination of biomechanical force-induced endothelial gene expression profiles. This review provides an overview of biomechanical force-induced modulation of endothelial phenotype. It examines the effect of sustained laminar shear stress (LSS), a type of uniform shear stress, on in vitro endothelial gene expression by synthesizing data from the early candidate gene and differential display polymerase chain reaction (PCR) approaches to the numerous, recent, high throughput functional genomic analyses. These studies demonstrate that prolonged LSS regulates the expression of only a small perce...Continue Reading

References

Dec 1, 1992·The Journal of Experimental Medicine·A S NeishT Collins
Dec 1, 1992·Matrix : Collagen and Related Research·G P Vadiakas, A J Banes
Nov 11, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·N DePaolaC F Dewey
Jan 1, 1990·Annals of the New York Academy of Sciences·P Constantinides, M Harkey
Jun 15, 1989·Biochemical and Biophysical Research Communications·M YoshizumiY Yazaki
Jul 1, 1989·Journal of Applied Physiology·F K WinstonL E Thibault
Jun 1, 1989·Journal of Cellular Physiology·S F GorfienE J Macarak
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P F DaviesM A Gimbrone
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·B L LangilleR L Kline
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M J LevesqueR M Nerem
May 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D N KuS Glagov
Nov 1, 1985·Journal of Biomechanical Engineering·M J Levesque, R M Nerem
Jan 1, 1972·Atherosclerosis·H P Wright
Oct 1, 1971·Circulation·Z Vlodaver, J E Edwards
Jul 1, 1984·Microvascular Research·S G EskinL T Navarro
Aug 1, 1981·Journal of Biomechanical Engineering·C F DeweyP F Davies
Jan 17, 1995·Annals of the New York Academy of Sciences·J AndoA Kamiya
Jan 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·P L WalpolaB L Langille
Jan 26, 1995·Biochemical and Biophysical Research Communications·H TsuboiA Kamiya
Apr 1, 1995·Journal of Cellular Physiology·K Muta, S B Krantz
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·U HoltrichK Strebhardt
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y J ShyyS Chien
Jan 1, 1993·Journal of Cellular Physiology·H J HsiehJ A Frangos
Dec 1, 1995·The American Journal of Physiology·M UematsuD G Harrison
Aug 14, 1996·Biochemical and Biophysical Research Communications·J AndoA Kamiya
Dec 9, 1996·FEBS Letters·S DimmelerA M Zeiher

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Citations

Mar 5, 2008·Journal of Biomedical Optics·Jian LuMorteza Gharib
Feb 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Beerend P HierckRobert E Poelmann
Dec 7, 2007·Seminars in Immunopathology·Peter S Tobias, Linda K Curtiss
Apr 9, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kris Noel DahlKerem Pekkan
Apr 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Robert D ShepherdKristina D Rinker
Dec 24, 2014·British Journal of Cancer·X ZhuangR Bicknell
Nov 22, 2017·Nature Communications·Julia J MackM Luisa Iruela-Arispe
Sep 1, 2009·Expert Review of Endocrinology & Metabolism·Johan OlerudPer-Ola Carlsson
May 13, 2006·Pediatric Research·Jay R Hove
Mar 2, 2006·Toxicologic Pathology·Bradley E EnersonEugenia Floyd
Feb 7, 2009·Biotechnology Progress·Sarah Stolberg, Kara E McCloskey
Nov 23, 2011·Biochemical Society Transactions·Xiaodong ZhuangRoy Bicknell
Sep 29, 2009·Annual Review of Fluid Mechanics·Daniel M SforzaJuan Raul Cebral
Nov 22, 2011·In Vitro Cellular & Developmental Biology. Animal·Anastasia D EgorovaBeerend P Hierck
Dec 1, 2017·Stereotactic and Functional Neurosurgery·Yun-Sik DhoHyun-Tai Chung
Dec 6, 2018·Advanced Healthcare Materials·Ini-Isabée WitzelJeremy C M Teo
Nov 6, 2010·Antioxidants & Redox Signaling·Patrizia NigroBradford C Berk
Dec 22, 2007·Toxicologic Pathology·Sabine RehmRogely W Boyce
May 24, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anastasia D EgorovaBeerend P Hierck
Nov 7, 2019·International Journal of Environmental Research and Public Health·Marzena RatajczakJoanna Karolkiewicz
Aug 5, 2005·Annals of Biomedical Engineering·Gordon M RihaChangyi Chen
Nov 23, 2007·Biochemical Society Transactions·P S Tobias, L K Curtiss
Feb 5, 2005·Pathophysiology of Haemostasis and Thrombosis·Gordon D O Lowe
Nov 5, 2008·Journal of Lipid Research·Linda K Curtiss, Peter S Tobias
Mar 14, 2019·Physiological Reviews·Sonsoles Piera-Velazquez, Sergio A Jimenez
Mar 7, 2007·Annals of Biomedical Engineering·Charles I JonesB Rita Alevriadou
Jan 22, 2011·Biomechanics and Modeling in Mechanobiology·Timothy M MaulDavid A Vorp
Nov 10, 2011·Lymphatic Research and Biology·Mikah Coffindaffer-WilsonJay R Hove
Aug 9, 2008·Microvascular Research·Luciano A Guerreiro-LucasChristopher A Mitchell
Sep 1, 2005·Analytical Chemistry·Omid C FarokhzadRobert Langer

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