PMID: 9528921Apr 7, 1998Paper

Adaptation of the fluid percussion injury model to the mouse

Journal of Neurotrauma
W S CarbonellM Sean Grady

Abstract

Fluid percussion injury (FPI) is a well-characterized experimental model of traumatic brain injury (TBI) in the rat. Many pathophysiologic consequences and mechanisms of recovery after TBI rely on neurochemical pathways that can be examined in genetically altered mice. Therefore, FPI applied to mice may be a useful experimental tool to investigate TBI at the molecular level. In the present study, we establish FPI as a viable model of TBI in the mouse by characterizing acute neurological, histopathological, and behavioral changes. Right-sided parasagittal FPI or sham treatment was administered in male C57BL/6 mice. Acute neurological evaluation revealed righting reflexes in the injured animals (p < 0.001). Deficits in spatial learning and memory were observed in the Morris water maze (MWM) 5 and 6 days after injury. A novel MWM data analysis protocol is described. The injured group (n = 18) demonstrated impaired performance in the MWM during acquisition (p < 0.05) and probe trials (p < 0.025) compared to sham animals (n = 16). At 7 days postinjury, glial fibrillary acidic protein immunohistochemistry revealed intense cortical, callosal, and hippocampal gliosis. The modified Gallyas silver degeneration stain consistently labeled ...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Oct 1, 1991·Journal of Neuroscience Methods·C E DixonR L Hayes
Jan 1, 1988·Behavior Genetics·M Upchurch, J M Wehner
Jul 1, 1987·Journal of Neurosurgery·C E DixonR L Hayes
May 1, 1987·Pharmacology, Biochemistry, and Behavior·M Upchurch, J M Wehner
Jan 1, 1983·Methods in Enzymology·J V Nadler, D A Evenson
Mar 14, 1983·Brain Research·D K ReinsteinR J Wurtman
May 1, 1982·Behavioral and Neural Biology·S J MizumoriM G Kermisch
Jun 1, 1995·Pharmacology & Toxicology·I ErreboeE T Mellerup
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·H SymondsT Van Dyke
Aug 1, 1994·Journal of Neurotrauma·T A Gennarelli
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R C CrumrineP F Morgan
Oct 29, 1993·Science·J A Deutsch
Jan 1, 1995·Experimental Brain Research·T M ReevesJ T Povlishock
Jul 1, 1996·Journal of Neurochemistry·F Jursky, N Nelson
Dec 1, 1993·Journal of Neuroendocrinology·T R InselD Crews
May 1, 1996·Trends in Neurosciences·J N Crawley
May 1, 1996·Trends in Neurosciences·W E Crusio
Dec 1, 1996·Acta Neuropathologica·K J McKenzieD I Graham
Feb 1, 1997·Experimental Neurology·J R LeonardL E Westrum
Jul 11, 1997·Brain Research·A MontkowskiF Holsboer
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Oct 29, 1993·Science·A J SilvaS Tonegawa
Oct 29, 1993·Science·S G GrantE R Kandel

❮ Previous
Next ❯

Citations

Jan 8, 2004·Brain Research Bulletin·Gunnar GrantH Aldskogius
Aug 23, 2001·Brain Research. Brain Research Reviews·R D'Hooge, P P De Deyn
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey T ColeAkiva S Cohen
Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
Sep 9, 2006·Journal of Neurotrauma·Lorriann D TranM Sean Grady
Aug 23, 2007·Journal of Neurotrauma·Ronald J FijalkowskiThomas A Gennarelli
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Michael FrinkFrank Hildebrand
Mar 2, 2013·Journal of Neuroinflammation·Susanne M SchwarzmaierNikolaus Plesnila
Aug 17, 2010·Experimental & Translational Stroke Medicine·Christiane Albert-Weissenberger, Anna-Leena Sirén
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Ibolja Cernak
Nov 13, 2001·Journal of Neurosurgery·H L LaurerT K McIntosh
Aug 31, 2011·Journal of Visualized Experiments : JoVE·Janet AlderSmita Thakker-Varia
Jul 6, 2013·Regenerative Medicine·Eric M GoldBrian J Cummings
Feb 5, 2014·Translational Stroke Research·Yi Ping ZhangChristopher B Shields
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
Jan 23, 2016·Experimental Neurology·Christopher P PalmerAkiva S Cohen
Feb 11, 2000·Annals of the New York Academy of Sciences·W S Carbonell, M S Grady
May 7, 2009·Neuroscience Letters·Coleen M AtkinsW Dalton Dietrich
Sep 7, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shaoyi ChenBingren R Hu
Mar 30, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Coleen M AtkinsBing-Ren Hu
Dec 17, 2014·Neuroscience and Biobehavioral Reviews·Corina O BondiAnthony E Kline
Aug 2, 2007·The European Journal of Neuroscience·Coleen M AtkinsW Dalton Dietrich
Dec 24, 2010·British Journal of Pharmacology·Niklas Marklund, Lars Hillered
Feb 15, 2012·Brain Research·Shenghui LiJianning Zhang
Sep 19, 2006·Experimental Gerontology·Syed A ShahHelen L Hellmich
Nov 19, 2015·Reviews in the Neurosciences·Shammy ChandelBikash Medhi
Nov 7, 2014·Frontiers in Neurology·Ibolja CernakStefan Plantman
Aug 18, 2016·Frontiers in Neuroscience·Eun Hyuk ChangFrancis G Szele
Aug 19, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James L KirklandFelipe Sierra
Dec 3, 2016·Laboratory Animals·Sarah PinkernellUte Lindauer
Jan 27, 2017·Brain Sciences·Damir Nizamutdinov, Lee A Shapiro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.