Adaptation to intermittent stress promotes maintenance of beta-cell compensation: comparison with food restriction

American Journal of Physiology. Endocrinology and Metabolism
Holly E BatesMladen Vranic

Abstract

Intermittent restraint stress delays hyperglycemia in ZDF rats better than pair feeding. We hypothesized that intermittent stress would preserve beta-cell mass through distinct mechanisms from food restriction. We studied temporal effects of intermittent stress on beta-cell compensation during pre-, early, and late diabetes. Six-week-old obese male ZDF rats were restraint-stressed 1 h/day, 5 days/wk for 0, 3, 6, or 13 wk and compared with age-matched obese ZDF rats that had been food restricted for 13 wk, and 19-wk-old lean ZDF rats. Thirteen weeks of stress and food restriction lowered cumulative food intake 10-15%. Obese islets were fibrotic and disorganized and not improved by stress or food restriction. Obese pancreata had islet hyperplasia and showed evidence of neogenesis, but by 19 wk old beta-cell mass was not increased, and islets had fewer beta-cells that were hypertrophic. Both stress and food restriction partially preserved beta-cell mass at 19 wk old via islet hypertrophy, whereas stress additionally lowered alpha-cell mass. Concomitant with maintenance of insulin responses to glucose, stress delayed the sixfold decline in beta-cell proliferation and reduced beta-cell hypertrophy, translating into 30% more beta-cel...Continue Reading

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Citations

Oct 22, 2015·The Journal of Endocrinology·Toya M Albury-WarrenDeborah A Altomare
Apr 18, 2013·Brain Research Bulletin·Nadezhda Bazhan, Dóra Zelena
Jul 15, 2009·Diabetes Research and Clinical Practice·Michael KharoutaManami Hara
May 5, 2012·Diabetes/metabolism Research and Reviews·Jacqueline L Beaudry, Michael C Riddell
Dec 19, 2015·Journal of Applied Physiology·Signe Tellerup NielsenRikke Krogh-Madsen
Sep 9, 2010·American Journal of Physiology. Endocrinology and Metabolism·Mladen Vranic
Jul 25, 2020·Diabetes Care·Alan Cherrington, Shirya Rashid
Nov 17, 2020·Frontiers in Genetics·Shaza AsifKyoung-Han Kim

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