Adaptation to repeated restraint stress in rats: failure of ethanol-treated rats to adapt in the stress schedule

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Darakhshan Jabeen Haleem

Abstract

Adaptation to a repeated restraint stress schedule was monitored in ethanol-treated and control rats. A single episode of 2 h restraint decreased food intake in both control and ethanol-treated rats. The decreases in control rats were not observed following the 5th daily restraint of 2 h/day, suggesting that adaptation has occurred. Ethanol-treated rats, however, exhibited decreased food intake even after 5th daily restraint of 2 h/day. Ethanol administration decreased weekly but not daily cumulative food intake in unrestrained rats. Food intakes of ethanol-treated and control restrained rats were comparable following 1st-3rd daily restraints, but were smaller in ethanol-treated rats following the 4th and 5th daily restraints. Open-field ambulatory activities monitored 24 h after the 5th daily restraint on the 6th day were comparable in control restrained and unrestrained rats. Ethanol-treated and control unrestrained rats also exhibited comparable ambulation, but ethanol-treated rats exhibited smaller activity than control restrained or ethanol-treated unrestrained rats. Fluid intakes of ethanol and control rats were comparable during the 2 weeks of ethanol administration, but daily restraint schedule decreased ethanol intake....Continue Reading

Citations

Aug 19, 2011·Psychopharmacology·Howard C BeckerTamara L Doremus-Fitzwater
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Darakhshan J HaleemMohammad A Haleem
Jul 1, 1999·Clinical and Experimental Pharmacology & Physiology·O AinsahB A Khalid
Oct 17, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Minoru TsujiHiroshi Takeda
Mar 17, 2007·The International Journal of Neuroscience·Darakhshan J HaleemM A Haleem
Apr 9, 2013·Journal of Neuroscience Methods·Michael D ReedMarcelo Febo
Oct 3, 2013·Pharmacology, Biochemistry, and Behavior·Darakhshan Jabeen HaleemMuhammad Abdul Haleem

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