PMID: 11927381Apr 3, 2002Paper

Adaptation to sustained high plasma vasopressin in water and electrolyte homeostasis in the rat transgenic for the metallothionein-vasopressin fusion gene

The Journal of Endocrinology
H YokoiYutaka Oiso

Abstract

Prolonged exposure of tissues to a receptor agonist often leads to adaptive changes that limit the subsequent responsiveness of the tissue to the same agonist. Recently, we have generated rats transgenic for the metallothionein I-human arginine vasopressin (AVP) fusion gene (Tg), which produced high plasma AVP with relatively preserved renal water excretion, suggesting that there might be adaptive mechanism(s) for maintaining water and electrolyte homeostasis against chronic AVP oversecretion from the earliest stage of life. In this study, to investigate whether down-regulation of AVP V2 receptor (V2R), which could possibly be caused by long-standing high plasma AVP, participates in this adaptive mechanism(s), non-peptidic V2R antagonist OPC31260 was administered to reverse the down-regulation, and water loading was performed after V2R antagonist treatment had been withdrawn. Additionally, to confirm the down-regulation, Northern blotting analysis for V2R mRNA was carried out. Tg rats showed slightly decreased urine volume and water intake with an equivalent plasma [Na(+)] level (Tg 140.4 +/- 0.6 mEq/l; control 139.3 +/- 0.6 mEq/l) under basal conditions. After water loading using a liquid diet containing zinc, which stimulates...Continue Reading

Citations

Jun 4, 2008·Seminars in Nephrology·Vicente E Torres
Jun 16, 2009·Journal of Neuroendocrinology·Shintaro IwamaYutaka Oiso
Jan 11, 2007·American Journal of Physiology. Renal Physiology·Yuichiro IzumiKimio Tomita
Aug 14, 2003·American Journal of Physiology. Endocrinology and Metabolism·Kazushige TachikawaYutaka Oiso

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