Adaptational changes in renal vacuolar H(+)-ATPase in the rat remnant kidney.

Journal of the American Society of Nephrology : JASN
B Bastani, S Gluck

Abstract

After 7/8 nephrectomy, the remnant kidney exhibits an adaptive increase in acid secretion per nephron. We studied the role of the kidney vacuolar H(+)-ATPase in this adaptational response by anti-H(+)-ATPase immunocytochemistry in kidneys from rats subjected to 7/8 nephrectomy or a sham procedure at 1, 2, and 3 wk after surgery. No changes in H(+)-ATPase staining were apparent in the proximal tubule, thick ascending limb, or distal convoluted tubule. In the cortical collecting ducts, the percentage of intercalated cells with well-polarized apical and well-polarized basolateral H(+)-ATPase staining was significantly higher in the remnant kidneys at 1, 2, and 3 wk. In the medullary intercalated cells of the sham-operated kidneys, relatively few cells had predominant plasma membrane H(+)-ATPase staining. In the remnant kidneys, the percentage of medullary intercalated cells with predominant plasma membrane H(+)-ATPase staining was increased significantly at 1 and 2 wk after surgery, returning to sham-operated values at 3 wk. The results indicate that intercalated cells in the collecting ducts of both cortex and medulla participate in the adaptation to reduction in renal mass by changing the steady-state distribution of H(+)-ATPase...Continue Reading

Citations

Aug 3, 2004·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Keith P ChoeSusan L Edwards
Jul 27, 2007·American Journal of Physiology. Renal Physiology·Hye-Young KimI David Weiner
Oct 17, 2017·Advances in Chronic Kidney Disease·Glenn T Nagami, L Lee Hamm

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