Adaptational responses to prolonged beta-adrenoceptor blockade in adult rabbits

British Journal of Pharmacology
A E Raine, E M Vaughan Williams

Abstract

1 A method for measuring propranolol concentrations in plasma has been modified to permit estimations to be made on small volumes. The method has been used to correlate blockade of heart rate increases in response to intravenous isoprenaline, in both young and adult rabbits, with plasma concentrations of propranolol after subcutaneous injections of 2 or 4 mg/kg. It has been found that the relation between beta-adrenoceptor blockade and plasma concentrations is the same in rabbits as that determined by previous workers in man. 2 Adult Dutch dwarf rabbits were treated for 9 weeks twice daily subcutaneously with 2 mg/kg propranolol, or 10 mg/kg practolol, or with saline. 3 The treatment caused no change in heart weight in relation to body weight or in the water content of the hearts, in contrast to effects previously observed in young rabbits. 4 As in the young rabbits, treatment did cause a prolongation of action potential duration, as measured with intracellular electrodes in hearts of animals killed 24 h after the last dose of drug. 5 In another series of experiments, with a similar regime of treatment for 6 weeks, a significant reduction of diastolic blood pressure was observed in the propranolol group. 6 During the course of ...Continue Reading

References

Dec 1, 1975·Clinical Pharmacology and Therapeutics·D G McDevitt, D G Shand
Jul 9, 1977·British Medical Journal·A E Raine, T G Pickering
Jul 1, 1975·Circulation·A S Nies, D G Shand
Oct 7, 1971·The New England Journal of Medicine·D G ShandJ A Oates
Nov 1, 1974·Circulation Research·S SenF M Bumpus
Sep 26, 1970·British Medical Journal·D J Coltart, D G Shand
Sep 1, 1971·British Journal of Pharmacology·J D Fitzgerald, S R O'Donnell
Sep 20, 1973·The New England Journal of Medicine·S L FaulknerD G Shand
Dec 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·D G ShandA S Nies
Jan 1, 1970·Clinical Pharmacology and Therapeutics·D G ShandJ A Oates

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Citations

Dec 5, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Antony J Workman
Sep 24, 1982·European Journal of Pharmacology·E M Williams, T J Campbell
Mar 1, 1995·Pacing and Clinical Electrophysiology : PACE·J P Claudel, P Touboul
Jul 1, 1987·Disease-a-month : DM·P J SchmidtP Denes
Mar 20, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jan KlimasSimon W Rabkin
Aug 31, 1987·The American Journal of Cardiology·F J VendittiJ N Ruskin
Apr 1, 1984·Journal of Clinical Pharmacology·E M Vaughan Williams

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