Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats

Neuropharmacology
Adrie W Bruijnzeel, A Markou

Abstract

Chronic administration of nicotine induces adaptations in the brain reward circuit to counteract the acute drug effects; when nicotine administration ceases, these adaptations remain unopposed and lead to drug withdrawal. The present studies were conducted to assess the effects of chronic nicotine administration on nicotinic acetylcholine receptor (nAChR) activity in the ventral tegmental area (VTA) and the nucleus accumbens (Nacc) shell. A discrete-trial intracranial self-stimulation procedure that provides current-intensity thresholds as measures of brain reward function was used in rats. Previous studies have shown that withdrawal from nicotine-induced elevations in brain reward thresholds that are indicative of a decrease in brain reward function. We show here that injections of the nAChR antagonist dihydro-beta-erythroidine (DHbetaE; 0.6-20 microg total bilateral dose) into the VTA, but not outside the VTA, resulted in significant elevations in brain reward thresholds in nicotine dependent rats (9 mg/kg/day nicotine hydrogen tartrate) while having no effect in saline-treated controls. By contrast, DHbetaE (0.6-20 microg total bilateral dose) injected into the Nacc shell had no effect on brain reward thresholds of nicotine-...Continue Reading

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Citations

Apr 24, 2007·Neurotoxicity Research·Neil E Paterson, Athina Markou
Jan 11, 2007·Psychopharmacology·Adrie W BruijnzeelMark S Gold
Nov 26, 2009·Psychopharmacology·Elysia SmallAdrie W Bruijnzeel
Feb 1, 2012·Human Genetics·Allison B Gold, Caryn Lerman
Nov 5, 2005·Brain Research. Brain Research Reviews·Adrie W Bruijnzeel, Mark S Gold
Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Catherine A MarcinkiewczAdrie W Bruijnzeel
Sep 1, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adrie W BruijnzeelMark S Gold
Nov 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sietse JonkmanAthina Markou
Jan 11, 2008·The Journal of Pharmacology and Experimental Therapeutics·K J JacksonM I Damaj
Aug 1, 2009·The Journal of Pharmacology and Experimental Therapeutics·K J JacksonM I Damaj
Mar 13, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jennifer A Davis, Thomas J Gould
Sep 20, 2005·Biological Psychiatry·Adrie W BruijnzeelMark Gold
Nov 30, 2014·Neuropharmacology·K J JacksonM I Damaj
Apr 4, 2015·Neuropharmacology·Elena V RadchenkoAnton Y Bespalov
Jul 28, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Xiaoli QiAdriaan W Bruijnzeel
Mar 3, 2009·Journal of Psychopharmacology·K A BrennanP Truman
Nov 20, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Song XueAdriaan W Bruijnzeel
Dec 2, 2019·Psychopharmacology·Anjelica CardenasShahrdad Lotfipour
Dec 29, 2016·Psychopharmacology·Adriaan W Bruijnzeel
Jan 8, 2021·Psychopharmacology·Ranjithkumar ChellianAdriaan W Bruijnzeel
May 15, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ranjithkumar ChellianAdriaan W Bruijnzeel

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