Adaptations of alpha2- and beta-cells of rat and mouse pancreatic islets to starvation, to refeeding after starvation, and to obesity

The Journal of Clinical Investigation
Franz M MatschinskyW T Norfleet

Abstract

The effects of starvation and refeeding and of obesity on pancreatic alpha2- and beta-cell responses to glucose or tolbutamide were studied with the isolated rat or mouse pancreas perfused with an amino acid mixture in the presence and absence of glucose. It was observed that the physiological adaptation to a regimen of fasting and realimentation and to obesity differed greatly in the two types of endocrine cells. Whereas beta-cells of rats showed a dramatic reduction of glucose- and tolbutamide-stimulated insulin release during starvation that was reversed by refeeding, alpha2-cells preserved their response to stimulators and inhibitors during this experimental manipulation. Amino acid stimulation of glucagon release occurred equally well with the pancreas from fed and starved rats and was suppressed efficiently by glucose and tolbutamide in both nutritional states. Surprisingly, the rate of onset of glucose suppression of alpha2-cells was significantly higher in the fasted than in the fed state. This glucose hypersensitivity was apparent 2 d after after food deprivation and had disappeared again on the 2nd d of refeeding. In the pancreas from animals starved for 3 d, glucose and tolbutamide suppression of alpha2-cells took pl...Continue Reading

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Citations

Oct 15, 1984·Experientia·D Pipeleers
Nov 1, 1983·Peptides·G AponteT Yamada
Apr 18, 2009·Nature Reviews. Drug Discovery·Franz M Matschinsky
Dec 26, 2012·The Journal of Biological Chemistry·Changhong LiAli Naji
Mar 1, 1984·The Journal of Clinical Investigation·S Kadowaki, A W Norman
Apr 30, 2008·Metabolism: Clinical and Experimental·Vanessa A G GiozzetJosé R Bosqueiro
Dec 1, 1983·Clinical Endocrinology·F P AlfordS Whitehouse
Feb 1, 1986·Clinics in Endocrinology and Metabolism·E SamolsG C Weir
Feb 1, 1984·Metabolism: Clinical and Experimental·T G HelinekJ F Caro
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Sep 1, 1983·The American Journal of Physiology·L PenicaudJ Le Magnen
Dec 1, 1983·The American Journal of Physiology·A L VallerandL J Bukowiecki

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