Adaptations of cytoarchitecture in human dilated cardiomyopathy

Biophysics Reviews
Marlene PluessElisabeth Ehler

Abstract

Hypertrophic cardiomyopathy is characterised by a histological phenotype of myocyte disarray, but heart tissue samples from patients with dilated cardiomyopathy (DCM) often look comparatively similar to those from healthy individuals apart from conspicuous regions of fibrosis and necrosis. We have previously investigated subcellular alterations in the cytoarchitecture of mouse models of dilated cardiomyopathy and found that both the organisation and composition of the intercalated disc, i.e. the specialised type of cell-cell contact in the heart, is altered. There is also is a change in the composition of the M-band of the sarcomere due to an expression shift towards the more extensible embryonic heart (EH)-myomesin isoform. Analysis of human samples from the Sydney Human Heart Tissue Bank have revealed similar structural findings and also provided evidence for a dramatic change in overall cardiomyocyte size control, which has also been seen in the mouse. Together these changes in cytoarchitecture probably contribute to the decreased functional output that is seen in DCM.

References

Jan 1, 1985·Tissue & Cell·M S Forbes, N Sperelakis
Feb 14, 1998·The Journal of Clinical Investigation·M A SussmanT R Kimball
Apr 1, 2000·The Journal of Biological Chemistry·I AgarkovaJ C Perriard
Jun 9, 2000·Annual Review of Physiology·W R MacLellan, M D Schneider
May 16, 2001·The Journal of Cell Biology·E EhlerJ C Perriard
Oct 30, 2001·Anatomy and Embryology·M LeuJ C Perriard
Jan 30, 2003·Trends in Cardiovascular Medicine·Jean-Claude PerriardElisabeth Ehler
May 14, 2005·Journal of Molecular Biology·Roman SchoenauerIrina Agarkova
Aug 3, 2005·Trends in Cell Biology·Irina Agarkova, Jean-Claude Perriard
Jun 4, 2008·Cardiovascular Research·Nicholas J SeversStephen Rothery
Aug 14, 2010·Journal of Muscle Research and Cell Motility·O'Neal CopelandSteven B Marston
Nov 5, 2010·Journal of Molecular and Cellular Cardiology·Gábor FöldesSian E Harding
Nov 12, 2010·Basic Research in Cardiology·Roman SchoenauerIrina Agarkova
Feb 1, 2011·Experimental Cell Research·Shajia LuRobert Horowits
Jul 20, 2011·Basic Research in Cardiology·Snigdha TripathiTheresia Kraft
Feb 18, 2012·The New England Journal of Medicine·Daniel S HermanChristine E Seidman
May 28, 2013·Cellular and Molecular Life Sciences : CMLS·Amanda J WilsonPauline M Bennett
Apr 29, 2014·Cell Communication & Adhesion·Alexia Vite, Glenn L Radice
Aug 16, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Joseph DwyerElisabeth Ehler

❮ Previous
Next ❯

Citations

Jan 26, 2018·Journal of Cardiovascular Development and Disease·Marco Luciani, Federica Del Monte
Jul 8, 2018·Circulation. Heart Failure·Tatsuya KagemotoShin'ichi Ishiwata
Jun 23, 2016·Journal of Muscle Research and Cell Motility·Pauline M BennettAmanda J Wilson
Jul 17, 2018·Biophysics Reviews·Katja Gehmlich, Elisabeth Ehler
Jul 20, 2018·Biophysics Reviews·C G Dos RemediosS Lal
Jun 30, 2016·Nature Communications·Stephan LangeElisabeth Ehler

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
confocal microscopy
light microscopy

Software Mentioned

LAS AF Lite

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

© 2022 Meta ULC. All rights reserved