Adaptations of skeletal muscle to prolonged, intense endurance training

Clinical and Experimental Pharmacology & Physiology
John A Hawley

Abstract

1. Endurance exercise induces a variety of metabolic and morphological responses/adaptations in skeletal muscle that function to minimize cellular disturbances during subsequent training sessions. 2. Chronic adaptations in skeletal muscle are likely to be the result of the cumulative effect of repeated bouts of exercise, with the initial signalling responses leading to such adaptations occurring after each training session. 3. Recently, activation of the mitogen-activated protein kinase signalling cascade has been proposed as a possible mechanism involved in the regulation of many of the exercise-induced adaptations in skeletal muscle. 4. The protein targets of AMP-activated protein kinase also appear to be involved in both the regulation of acute metabolic responses and chronic adaptations to exercise. 5. Endurance training is associated with an increase in the activities of key enzymes of the mitochondrial electron transport chain and a concomitant increase in mitochondrial protein concentration. These morphological changes, along with increased capillary supply, result in a shift in trained muscle to a greater reliance on fat as a fuel with a concomitant reduction in glycolytic flux and tighter control of acid-base status. T...Continue Reading

References

Jan 1, 1977·Annals of the New York Academy of Sciences·B SaltinE Jansson
Feb 1, 1976·Journal of Applied Physiology·D L CostillB Saltin
Jan 1, 1976·Annual Review of Physiology·J O Holloszy, F W Booth
Mar 1, 1976·Acta Physiologica Scandinavica·B SaltinD Gollnick
Apr 1, 1975·The American Journal of Physiology·R H FittsJ O Holloszy
Jan 1, 1977·Annals of the New York Academy of Sciences·J O HolloszyJ M Hagberg
Mar 1, 1992·Molecular and Cellular Biology·R H ChenJ Blenis
Jan 1, 1991·Medicine and Science in Sports and Exercise·E F CoyleG W Petrek
Oct 1, 1990·Journal of Applied Physiology·C L StebbinsJ C Longhurst
Jun 1, 1988·Journal of Applied Physiology·E F CoyleT J Walters
Feb 1, 1986·Journal of Applied Physiology·B F HurleyJ O Holloszy
Oct 1, 1973·The American Journal of Physiology·K M BaldwinJ O Holloszy
Mar 1, 1974·The American Journal of Physiology·I R Wendt, C L Gibbs
Jun 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·J KarlssonB Saltin
Sep 1, 1972·Journal of Applied Physiology·P D GollnickB Saltin
Oct 1, 1967·Acta Physiologica Scandinavica·L HermansenB Saltin
Oct 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A DudleyR L Terjung
Apr 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J O Holloszy, E F Coyle
Dec 1, 1993·The American Journal of Physiology·P D Neufer, G L Dohm
Jan 1, 1997·European Journal of Applied Physiology and Occupational Physiology·A R WestonJ A Hawley
Mar 15, 1997·The Journal of Clinical Investigation·D AronsonL J Goodyear
Jan 1, 1997·European Journal of Applied Physiology and Occupational Physiology·C Westgarth-TaylorS C Dennis
Oct 8, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·U WidegrenJ R Zierath
May 20, 1999·Medicine and Science in Sports and Exercise·N K SteptoW G Hopkins
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·Z P ChenB E Kemp
Feb 24, 2001·Pflügers Archiv : European journal of physiology·U WidegrenJ Henriksson
Feb 27, 2001·Medicine and Science in Sports and Exercise·D B PyneK M Swanwick
Mar 10, 2001·Journal of Science and Medicine in Sport·A E JeukendrupJ A Hawley
Apr 12, 2001·Journal of Applied Physiology·G A Nader, K A Esser
Jun 29, 2001·Sports Medicine·J A Hawley, N K Stepto
Aug 18, 2001·Journal of Applied Physiology·W W Winder
Jul 27, 2007·Cell Biochemistry and Biophysics·William W Winder, David M Thomson
Sep 28, 2010·Exercise and Sport Sciences Reviews·John A Hawley, Louise M Burke

❮ Previous
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Citations

Aug 21, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Christophe M R LeMoineGrant B McClelland
Mar 7, 2013·European Journal of Applied Physiology·Jonathan P R ScottWilliam D Fraser
Oct 13, 2007·Heart Failure Reviews·Alessandro MezzaniPantaleo Giannuzzi
Dec 4, 2003·Biochemical and Biophysical Research Communications·Jakob N NielsenErik A Richter
Oct 7, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kathryn H Myburgh
May 1, 2010·Journal of Human Genetics·Vishnu Sarpeshkar, David J Bentley
Jun 13, 2006·Journal of Sports Sciences·John A HawleyMindy L Millard-Stafford
Dec 6, 2007·Journal of Sports Sciences·John A HawleyUNKNOWN International Association of Athletics Federations
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Malcolm J Jackson
Jan 4, 2008·Acta Physiologica·J A Hawley, S J Lessard
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·John A Hawley
Feb 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Wee Kian YeoJohn A Hawley
Nov 17, 2009·Journal of the International Society of Sports Nutrition·Jennifer L GraefJeffrey R Stout
Oct 16, 2004·PLoS Biology·Juleen R Zierath, John A Hawley
Jul 23, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Fabiana Braga BenattiAntonio Herbert Lancha
Sep 19, 2012·Journal of Aging Research·Nina HovanecAnthony A Vandervoort
Nov 23, 2013·Sports Medicine·Jonathan D BartlettJames P Morton
May 17, 2011·European Journal of Applied Physiology·Ricardo A PinhoClaudio T Souza
Nov 8, 2014·Extreme Physiology & Medicine·Pete J Cox, Kieran Clarke
Feb 16, 2016·Free Radical Biology & Medicine·Donny M CameraJohn A Hawley
Jun 14, 2012·Archives of Physiology and Biochemistry·Annika TaubeJuergen Eckel
Dec 25, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jan BooneJan Bourgois
Aug 17, 2010·Biochimica Et Biophysica Acta·Kay Ohlendieck
Oct 6, 2009·Advances in Chronic Kidney Disease·Thomas W Storer
Dec 24, 2015·Nutrition & Metabolism·Pim KnuimanMarco Mensink
Nov 11, 2015·Sports Medicine·John A Hawley, Jill J Leckey
Dec 4, 2015·Proteomics·Ana Isabel PadrãoJosé Alberto Duarte
Oct 19, 2006·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Joel D KoppleThomas Storer
Nov 25, 2014·Cell·John A HawleyJuleen R Zierath
Jul 15, 2015·Cell Metabolism·John A HawleyMark Hargreaves
Sep 25, 2010·Scandinavian Journal of Medicine & Science in Sports·P B Laursen
Jun 27, 2013·Scandinavian Journal of Medicine & Science in Sports·K VissingN Jessen
Aug 22, 2014·Clinical and Experimental Pharmacology & Physiology·John A Hawley, James P Morton

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