Adaptations to new environments in humans: the role of subtle allele frequency shifts.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Angela M HancockAnna Di Rienzo

Abstract

Humans show tremendous phenotypic diversity across geographically distributed populations, and much of this diversity undoubtedly results from genetic adaptations to different environmental pressures. The availability of genome-wide genetic variation data from densely sampled populations offers unprecedented opportunities for identifying the loci responsible for these adaptations and for elucidating the genetic architecture of human adaptive traits. Several approaches have been used to detect signals of selection in human populations, and these approaches differ in the assumptions they make about the underlying mode of selection. We contrast the results of approaches based on haplotype structure and differentiation of allele frequencies to those from a method for identifying single nucleotide polymorphisms strongly correlated with environmental variables. Although the first group of approaches tends to detect new beneficial alleles that were driven to high frequencies by selection, the environmental correlation approach has power to identify alleles that experienced small shifts in frequency owing to selection. We suggest that the first group of approaches tends to identify only variants with relatively strong phenotypic effect...Continue Reading

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Citations

Mar 25, 2011·Genetics Research·Brian Charlesworth
May 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Angela M HancockAnna Di Rienzo
Aug 21, 2013·Genome Biology and Evolution·Kaixiong YeZhenglong Gu
Oct 26, 2013·International Journal of Epidemiology·Jonathan C K Wells
Apr 30, 2013·Molecular Biology and Evolution·Josephine T DaubLaurent Excoffier
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Bonsall, Brian Charlesworth
Feb 9, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John Novembre, Eunjung Han
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Jul 10, 2013·Annual Review of Genomics and Human Genetics·Wenqing Fu, Joshua M Akey
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May 3, 2011·PLoS Genetics·Angela M HancockAnna Di Rienzo
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