Adaptative response of antioxidant enzymes in different areas of rat brain after repeated d-amphetamine administration

Addiction Biology
Félix CarvalhoMaria De Lourdes Bastos

Abstract

d-Amphetamine has been shown to be a potential brain neurotoxic agent, particularly to dopaminergic neurones. Reactive oxygen species indirectly generated by this drug have been indicated as an important factor in the appearance of neuronal damage but little is known about the adaptations of brain antioxidant systems to its chronic administration. In this study, the activities of several antioxidant enzymes in different areas of rat brain were measured after repeated administration of d-amphetamine sulphate (sc, 20 mg/kg/day, for 14 days), namely glutathione-S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GRed), catalase, and superoxide dismutase (SOD). When compared to a pair-fed control group, d-amphetamine treatment enhanced the activity of GST in hypothalamus to 167%, GPx in striatum to 127%, in nucleus accumbens to 192%, and in medial prefrontal cortex to 139%, GRed in hypothalamus to 139%, as well as catalase in medial prefrontal cortex to 153%. However, the same comparison revealed a decrease in the activity of GRed in medial pre-frontal cortex by 35%. Food restriction itself reduced GRed activity by 49% and enhanced catalase activity to 271% in nucleus accumbens. The modifications observed for ...Continue Reading

References

Aug 1, 1979·European Journal of Biochemistry·J López-Barea, C Y Lee
Feb 1, 1978·Biochemical Pharmacology·C M KuhnG R Breese
Jan 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J LiuE D Robin
May 1, 1975·British Journal of Pharmacology·G MitchellC Rosendorff
Jun 1, 1975·British Journal of Pharmacology·I M James, L Macdonell
Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Jan 1, 1984·Methods in Enzymology·L Flohé, F Otting
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Jan 1, 1984·Methods in Enzymology·H Aebi
Jun 1, 1980·Journal of Neurochemistry·P M SinetG Cohen
Jan 1, 1993·Critical Reviews in Biochemistry and Molecular Biology·V Daniel
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A Swanson, D W Choi
Mar 2, 1996·Lancet·H SatoO Koiwai
Sep 1, 1996·Chemical Research in Toxicology·F CarvalhoM L Bastos
Jun 1, 1999·Archives of Toxicology·F CarvalhoM de Lourdes Bastos
Jun 14, 2000·Progress in Neurobiology·I J MitchellM R Griffiths

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Citations

Jun 26, 2007·Neurological Research·Kranthi Kumari NagaPhanithi Prakash Babu
May 20, 2015·Molecular and Cellular Biochemistry·G E Mejia-CarmonaA Martínez-Martínez
Jul 30, 2002·The Journal of Biological Chemistry·Julie LothariusPatrik Brundin
Aug 16, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andreas Johannes SchmidtHelmut Vedder
Aug 18, 2012·Bipolar Disorders·Danielle S MacêdoAndré F Carvalho
Apr 4, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Samira S ValvassoriJoão Quevedo

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