Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells

International Journal of Molecular Sciences
Sabino RussiVitalba Ruggieri

Abstract

Despite the significant recent advances in clinical practice, gastric cancer (GC) represents a leading cause of cancer-related deaths in the world. In fact, occurrence of chemo-resistance still remains a daunting hindrance to effectiveness of the current approach to GC therapy. There is accumulating evidence that a plethora of cellular and molecular factors is implicated in drug-induced phenotypical switching of GC cells. Among them, epithelial-mesenchymal transition (EMT), autophagy, drug detoxification, DNA damage response and drug target alterations, have been reported as major determinants. Intriguingly, resistant GC phenotype may be the result of GC cell-induced tumor microenvironment (TME) remodeling, which is currently emerging as a key player in promoting drug resistance and overcoming cytotoxic effects of drugs. In this review, we discuss the possible mechanisms of drug resistance and their involvement in determining current GC therapies failure.

References

Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y KoderaH Takagi
Dec 1, 1996·Japanese Journal of Cancer Research : Gann·M TomonagaS Kohno
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·U KellnerS H Kaufmann
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jan 31, 2002·Annual Review of Medicine·Michael M Gottesman
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Dec 29, 2004·Annals of Surgery·Bryan J DickenStewart M Hamilton
May 20, 2005·The Journal of Pharmacy and Pharmacology·Yasuna KobayashiToshinori Yamamoto
Nov 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A GriffithsC M West
Jun 9, 2006·Cancer Biology & Therapy·Hanbing NingDaiming Fan
Mar 14, 2007·Cancer Cell·Michail ShipitsinKornelia Polyak
Nov 2, 2007·Nature Reviews. Cancer·Robin MathewEileen White
May 23, 2008·The Journal of Biological Chemistry·Xiaoying GuoMasanobu Oshima
Aug 8, 2009·The American Journal of Gastroenterology·Florin M SelaruJames P Hamilton
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eileen White, Robert S DiPaola
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Jul 28, 2010·Archives of Pharmacal Research·Tuong Vy Thi LeHyun-Ju Park
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joseph H TaubeSendurai A Mani
Mar 10, 2011·World Journal of Surgery·Carl C SchimanskiInes Gockel
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Noboru MizushimaYoshinori Ohsumi
Nov 18, 2011·World Journal of Gastroenterology : WJG·Guang-Xia ChenXiao-Hua He
Mar 13, 2012·World Journal of Gastroenterology : WJG·Wen-Xia KuaiXiao-Jun Tang
Mar 31, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Robert PartykaTomasz Byrczek
Jun 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naoki OishiXin Wei Wang
Oct 12, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rongfei HanQiuping Zhang
Dec 4, 2012·Indian Journal of Surgical Oncology·Vikram K JainSheela Rao
Jan 16, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elisabeth WikHelga B Salvesen

❮ Previous
Next ❯

Citations

Feb 6, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Shuai WangDongming Xing
Dec 13, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Marbelis Francisco FernandezBorhane Annabi
Jun 26, 2020·OncoTargets and Therapy·Xiaoya ZhaoWenxia Xu
Apr 25, 2020·International Journal of Molecular Sciences·Lucia MagnelliLaura Papucci
Jan 2, 2021·Frontiers in Molecular Biosciences·Xiaodong HuangYongbin Zheng
Dec 22, 2020·Frontiers in Cell and Developmental Biology·Jing-Li XuJiang-Jiang Qin
Jul 13, 2021·Frontiers in Oncology·Martina AddeoPellegrino Mazzone

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Related Concepts

Related Feeds

ATG proteins

The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

World Journal of Gastrointestinal Oncology
Wen-Jia Shi, Jin-Bo Gao
Journal of Thoracic Disease
Dakai Xiao, Jianxing He
International Journal of Molecular Sciences
Ismael RiquelmeJuan Carlos Roa
© 2021 Meta ULC. All rights reserved